Ragé M, Van Acker N, Knaapen MW, Timmers M, Streffer J, Hermans Mp, Sindic C, Meert T, Plaghki L. J Neurol (2011); 258(10):1852-64. [PDF]
Pain research at the Institute of Neuroscience (IONS)
Université catholique de Louvain (UCL)
The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.
Basic, translational and clinical pain research at the Institute of Neuroscience (IONS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute.
André Mouraux pain research EEG nociception letswave software analysis free matlab wavelets toolbox nocions
|Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.|
|The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.
|Letswave is a free toolbox to analyze electroencephalographic (EEG) and other neurophysiological signals, running in Matlab. As compared to existing signal processing toolboxes, emphasis is placed on intuitive and streamlined tools to process and visualize neurophysiological signals, with a shallow learning curve. The new version provides advanced scripting possibilities.|
Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potential.
Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1
Berger JV, Deumens R, Goursaud S, Schäfer S, Lavand'homme P, Joosten EA, Hermans E. J Neuroinflammation (2011); 8:33.
Multimodal therapeutic assessment of peripheral nerve stimulation in neuropathic pain: Five case reports with a 20-year follow-up.
Kupers R, Laere KV, Calenbergh FV, Gybels J, Dupont P, Baeck A, Plaghki L. Eur J Pain (2011); 15(2): 161.e1-9. [PDF]
Dishabituation of laser-evoked EEG responses: dissecting the effect of certain and uncertain changes in stimulus modality
Valentini E, Torta D, Mouraux A, Iannetti GD. J Cog Neurosci (2011) (in press). [PDF]
Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush
Gallo A, Dimiziani A, Damblon J, Michot B, Des Rieux A, De Kock M, Hermans E, Deumens R. Neurosci Res (2015); 95:78-82.
Berquin A. Rev Med Suisse (2010); 6(258):1511-3.
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Bypassing primary sensory cortices - a direct thalamocortical pathway for transmitting salient sensory information
Liang M, Mouraux A, Iannetti GD. Cereb Cortex (2013); 23(1): 1-11. [PDF]
Phillips-Silver J, Toiviainen P, Gosselin N, Piché O, Nozaradan S, Palmer C, Peretz I. Neuropsychologia (2011); 49(5): 961-969
Automated single-trial detection and quantification of evoked potentials, a potential tool for neuromonitoring?
Mouraux A, Guérit JM. Clin Neurophysiol (2011); 122(7): 1280-1. [PDF]
Van Ryckeghem D, Van Damme S, Crombez G, Eccleston C, Verhoeven K, Legrain V. Exp Brain Res (2011); 208(2): 269-275. [PDF]
Is distraction from pain influenced by executive functioning abilities? An experimental investigation of task switching and inhibition
Verhoeven K, Van Damme S, Eccleston C, Van Ryckeghem D, Legrain V,
Crombez G. Eur J Pain (2011) 208(2): 269-75.
Legrain V, Crombez G, Mouraux A. PLoS ONE (2011) 6(6): e20926. [PDF]
Legrain V, Crombez G, Verhoeven K, Mouraux A. Pain (2011); 152(2): 453-9. [PDF]
Legrain V, Iannetti GD, Plaghki L, Mouraux A. Prog Neurobiol (2011) 93(1); 111-124. [PDF]
Mouraux A, Diukova A, Lee MC, Wise RG, Iannetti GD. Neuroimage (2011); 54(3):2237-49. [PDF]
Van Damme S, Legrain V, Vogt J, Crombez G. Neurosci Biobehav Rev (2010);34(2):204-213.
The time course of CO2 laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteers.
Ragé M, Van Acker N, Facer P, Shenoy R, Knaapen MW, Timmers M, Streffer J, Anand P, Meert T, Plaghki L. Clin Neurophysiol (2010) 121(8):1256-66. [PDF]
Plaghki L, Decruynaere C, Van Dooren P, Le Bars D. PLoS One (2010) 5(4):e10269. [PDF]
Mouraux A, Iannetti GD, Plaghki L. Pain (2010) 150 (1):199-207. [PDF]
Iannetti GD, Mouraux A. Exp Brain Res (2010) 205(1):1-12. [PDF]
Stimulus novelty and not neural refractoriness explains the repetition suppression of laser-evoked potentials (LEPs)
Wang AL, Mouraux A, Liang M, Iannetti GD. J Neurophysiol (2010) 104(4):2116-24. [PDF]
Libouton X, Barbier O, Plaghki L, Thonnard JL. Behav Brain Res (2010); 208(2): 473-478.
Functional characterisation of sensory ERPs using probabilistic ICA: effect of stimulus modality and stimulus location.
Liang M, Mouraux A, Chan V, Blakemore C, Iannetti GD. Clin Neurophysiol (2010) 121(4):577-87. [PDF]
Rombaux P, Huart C, De Volder AG, Cuevas I, Renier L, Duprez T, Grandin C. Neuroreport (2010); 21(17): 1067-1073. [PDF]
Presence of olfactory event-related potentials predicts recovery in patients with olfactory loss following upper respiratory tract infection.
Rombaux P, Huart C, Collet S, Eloy P, Negoias S, Hummel T. Laryngoscope (2010); 120(10): 2115-2118. [PDF]
A novel approach for enhancing the signal-to-noise ratio and detecting automatically event-related potentials (ERPs) in single trials.
Hu L, Mouraux A, Hu Y, Iannetti GD. Neuroimage (2010); 50(1):99-111. [PDF]
Hatem SM, Attal N, Ducreux D, Gautron M, Parker F, Plaghki L, Bouhassira D. Brain (2010); 133(11):3409-22. [PDF]
Berquin AD, Lijesevic V, Blond S, Plaghki L. Muscle Nerve (2010); 42(3):328-38. [PDF]