NOCIONS
Pain research at the Institute of Neuroscience (IONS)
Université catholique de Louvain (UCL)

The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.

Basic, translational and clinical pain research at the Institute of Neuroscience (IONS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute. 

The research teams are based at the Institute of Neuroscience (IONS) of the Université catholique de Louvain (UCL).  See also the 2013-2014 and 2011-2012 activities report of the Institute.

André Mouraux pain research EEG nociception letswave software analysis free matlab wavelets toolbox nocions

Research team led by André Mouraux

Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

 

Research team led by Valery Legrain

The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
 

 

 
 
 
 

 

 

 

Research team led by Valery Legrain

The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
 

 

Research team led by Emmanuel Hermans


The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
 

 

Clinical pain research at the University Hospital


At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.

Letswave 6

Letswave is a free toolbox to analyze electroencephalographic (EEG) and other neurophysiological signals, running in Matlab. As compared to existing signal processing toolboxes, emphasis is placed on intuitive and streamlined tools to process and visualize neurophysiological signals, with a shallow learning curve. The new version provides advanced scripting possibilities. 
 
 

Publications

Exploring how musical rhythms entrain brain activity with EEG frequency-tagging

Nozaradan S. Phil Trans B (2014); 369(1658):20130393. [PDF]

Body movement selectively shapes the neural representation of musical rhythms

Chemin B, Mouraux A, Nozaradan S. Psychol Sci (2014); 25(12):2147-59. [PDF]

Olfactory event-related potentials in infants

Schriever VA, Gois-Eanes M, Schuster B, Huart C, Hummel T. J Pediatr (2014); 165(2): 372-375. [PDF]

Thermoregulatory vasomotor tone of the rat tail and paws in thermoneutral conditions and its impact on a behavioral model of acute pain

El Bitar N, Pollin B, Karroum E, Pincedé I, Mouraux A, Le Bars D. J Neurophysiol (2014); 112(9):2185-98 [PDF].

EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli

Colon E, Legrain V, Mouraux A. J Cog Neurosci (2014); 26(10):2262-74. [PDF]

Mapping nociceptive stimuli in a peripersonal frame of reference: Evidence from a temporal order judgment task

De Paepe A, Crombez G, Spence C, Legrain V. Neuropsychologia (2014); 56:219-28. [PDF]

Single-trial time-frequency analysis of electrocortical signals: baseline correction and beyond.

Hu L, Xiao P, Zhang ZG, Mouraux A, Iannetti GD. Neuroimage (2014); 84:876-8. [PDF]

Finite element analysis of thermal laser skin stimulation for a finer characterization of the nociceptive system

Marchandise E, Mouraux A, Plaghki L, Henrotte F. J Neurosci Methods (2014); 223: 1-10. [PDF].

Cognitive-motor interference while grasping, lifting and holding objects

Guillery E, Mouraux A, Thonnard JL. PLoS ONE (2013); 8(11):e80125 [PDF].

Capturing with EEG the neural entrainment and coupling underlying sensorimotor synchronization to the beat

Nozaradan S, Zerouali Y, Peretz I, Mouraux A. Cerebral Cortex (2013); 25(3):736-47. [PDF]

Plasticity of the human olfactory system : the olfactory bulb.

Huart C, Rombaux P, Hummel T. Molecules (2013); 18(9): 11586-600.

Schwann cell migration and neurite outgrowth are influenced by media conditioned by epineurial fibroblasts

van Neerven SG, Pannaye P, Bozkurt A, Van Nieuwenhoven F, Joosten E, Hermans E, Taccola G, Deumens R. Neuroscience (2013);252:144-53.

Unmasking the obligatory components of nociceptive event-related brain potentials

Mouraux A, De Paepe AL, Marot E, Plaghki L, Iannetti GD, Legrain V. J Neurophysiol (2013); 110(10):2312-24. [PDF].

Primary Sensory Cortices Contain Distinguishable Spatial Patterns of Activity for Each Sense

Liang M, Mouraux A, Hu L, Iannetti GD. Nature Communications (2013); 4:1979. [PDF]

Psychophysical and electrophysiological evidence for nociceptive dysfunction in CRPS

Caty G, Hu L, Legrain V, Plaghki L, Mouraux A. Pain (2013); 154(11):2521-8. [PDF]

Beyond metaphor: Contrasting mechanisms of social and physical pain.

Iannetti GD, Salomons TV, Moayedi M, Mouraux A, Davis KD. TRENDS in Cognitive Sciences (2013); 17(8): 371-8. [PDF]

Clinical usefulness and feasibility of time-frequency analysis of chemosensory event-related potentials

Huart C, Rombaux P, Hummel T, Mouraux A. Rhinology (2013); 51(3): 210-21. [PDF]

Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity

Leinders M, Knaepen L, De Kock M, Sommer C, Hermans E, Deumens R. Neurosci Lett (2013); 554:146-50.

Postoperative opioids: let us take responsibility for the possible consequences

Steyaert A, Lavand'homme P. Eur J Anaesthesiol (2013); 30(2):50-2. 

Shielding cognition from nociception with working memory

Legrain V, Crombez G, Plaghki L, Mouraux A. Cortex (2013); 49(7):1922-34. [PDF]

Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial.

Forget P, Berlière M, van Maanen A, Duhoux FP, Machiels JP, Coulie PG, Bouche G, De Kock M; Ketorolac in Breast Cancer trial (KBCtrial) group. Med Hypotheses (2013); 81(4):707-12.

Prognostic value of olfactory bulb volume measurement for recovery in postinfectious and posttraumatic olfactory loss.

Rombaux P, Huart C, Deggouj N, Duprez T, Hummel T. Otolaryngol Head Neck Surg (2012); 147(6):1136-41.

Novelty is not enough: laser-evoked potentials are determined by stimulus saliency, not absolute novelty.

Ronga I, Valentini E, Mouraux A, Iannetti GD. J Neurophysiol (2013); 109(3):692-701. [PDF]

Items: 61 - 90 of 224
<< 1 | 2 | 3 | 4 | 5 >>