van den Broeke EN, Mouraux A. J Neurophysiol (2014); 112(9):2059-66. [ PDF ]
Pain research at the Institute of Neuroscience (IONS)
Université catholique de Louvain (UCL)
The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.
Basic, translational and clinical pain research at the Institute of Neuroscience (IONS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute.
André Mouraux pain research EEG nociception letswave software analysis free matlab wavelets toolbox nocions
|Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.|
|The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.
|Letswave is a free toolbox to analyze electroencephalographic (EEG) and other neurophysiological signals, running in Matlab. As compared to existing signal processing toolboxes, emphasis is placed on intuitive and streamlined tools to process and visualize neurophysiological signals, with a shallow learning curve. The new version provides advanced scripting possibilities.|
Enhanced brain responses to C fiber input in the area of secondary hyperalgesia induced by high frequency electrical stimulation of the skin
Chemin B, Mouraux A, Nozaradan S. Psychol Sci (2014); 25(12):2147-59. [PDF]
Schriever VA, Gois-Eanes M, Schuster B, Huart C, Hummel T. J Pediatr (2014); 165(2): 372-375. [PDF]
Thermoregulatory vasomotor tone of the rat tail and paws in thermoneutral conditions and its impact on a behavioral model of acute pain
El Bitar N, Pollin B, Karroum E, Pincedé I, Mouraux A, Le Bars D. J Neurophysiol (2014); 112(9):2185-98 [PDF].
EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli
Colon E, Legrain V, Mouraux A. J Cog Neurosci (2014); 26(10):2262-74. [PDF]
Shifting attention between the space of the body and external space. Electrophysiological correlates of visual-nociceptive crossmodal spatial attention.
Favril L, Mouraux A, Sambo CS, Legrain V. Psychophysiol (2014); 51(5):464-77. [PDF]
Mapping nociceptive stimuli in a peripersonal frame of reference: Evidence from a temporal order judgment task
De Paepe A, Crombez G, Spence C, Legrain V. Neuropsychologia (2014); 56:219-28. [PDF]
High frequency electrical stimulation of human skin induces heterotopical mechanical and heat hyperalgesia and enhanced responses to vibrotactile input
van den Broeke EN, Mouraux A. J Neurophysiol (2014)111(8):1564-73. [PDF]
Hu L, Xiao P, Zhang ZG, Mouraux A, Iannetti GD. Neuroimage (2014); 84:876-8. [PDF]
Short trains of intra-epidermal electrical stimulation to elicit reliable behavioral and electrophysiological responses to the selective activation of nociceptors in humans.
Mouraux A, Marot E, Legrain V. Neurosci Lett (2014); 561: 69-73 [PDF].
Finite element analysis of thermal laser skin stimulation for a finer characterization of the nociceptive system
Marchandise E, Mouraux A, Plaghki L, Henrotte F. J Neurosci Methods (2014); 223: 1-10. [PDF].
Guillery E, Mouraux A, Thonnard JL. PLoS ONE (2013); 8(11):e80125 [PDF].
Capturing with EEG the neural entrainment and coupling underlying sensorimotor synchronization to the beat
Nozaradan S, Zerouali Y, Peretz I, Mouraux A. Cerebral Cortex (2013) (in press). [PDF]
Theta burst stimulation applied over primary motor and somatosensory cortices produces analgesia unrelated to the changes in nociceptive event-related potentials
Torta D, Legrain V, Algoet M, Olivier E, Duqué J, Mouraux A. PLoS ONE (2013) 20; 8(8): e73263. [PDF]
Huart C, Rombaux P, Hummel T. Molecules (2013); 18(9): 11586-600.
Schwann cell migration and neurite outgrowth are influenced by media conditioned by epineurial fibroblasts
van Neerven SG, Pannaye P, Bozkurt A, Van Nieuwenhoven F, Joosten E, Hermans E, Taccola G, Deumens R. Neuroscience (2013);252:144-53.
Mouraux A, De Paepe AL, Marot E, Plaghki L, Iannetti GD, Legrain V. J Neurophysiol (2013) (in press). [PDF].
Liang M, Mouraux A, Hu L, Iannetti GD. Nature Communications (2013); 4:1979. [PDF]
Caty G, Hu L, Legrain V, Plaghki L, Mouraux A. Pain (2013); in press. [PDF]
Iannetti GD, Salomons TV, Moayedi M, Mouraux A, Davis KD. TRENDS in Cognitive Sciences (2013); 17(8): 371-8. [PDF]
Clinical usefulness and feasibility of time-frequency analysis of chemosensory event-related potentials
Huart C, Rombaux P, Hummel T, Mouraux A. Rhinology (2013); 51(3): 210-21. [PDF]
Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity
Leinders M, Knaepen L, De Kock M, Sommer C, Hermans E, Deumens R. Neurosci Lett (2013); 554:146-50.
Reliable EEG responses to the selective activation of C-fibre afferents using a temperature-controlled infrared laser stimulator in conjunction with an adaptive staircase algorithm
Jankovski A, Plaghki L, Mouraux A. Pain (2013); 154(9): 1578-87. [PDF]
Steyaert A, Lavand'homme P. Eur J Anaesthesiol (2013); 30(2):50-2.
Legrain V, Crombez G, Plaghki L, Mouraux A. Cortex (2013); 49(7):1922-34. [PDF]
Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial.
Forget P, Berlière M, van Maanen A, Duhoux FP, Machiels JP, Coulie PG, Bouche G, De Kock M; Ketorolac in Breast Cancer trial (KBCtrial) group. Med Hypotheses (2013); 81(4):707-12.
Prognostic value of olfactory bulb volume measurement for recovery in postinfectious and posttraumatic olfactory loss.
Rombaux P, Huart C, Deggouj N, Duprez T, Hummel T. Otolaryngol Head Neck Surg (2012); 147(6):1136-41.
Novelty is not enough: laser-evoked potentials are determined by stimulus saliency, not absolute novelty.
Ronga I, Valentini E, Mouraux A, Iannetti GD. J Neurophysiol (2013); 109(3):692-701. [PDF]
Nozaradan S, Peretz I, Mouraux A. J Neurosci (2012); 32(49):17572-81. [PDF]
Steady-state evoked potentials to study the processing of tactile and nociceptive somatosensory input in the human brain.
Colon E, Legrain V, Mouraux A. Neurophysiol Clin (2012); 42(5):315-23. [PDF]