Leinders M, Knaepen L, De Kock M, Sommer C, Hermans E, Deumens R. Neurosci Lett (2013); 554:146-50.
Pain research at the Institute of Neuroscience (IONS)
Université catholique de Louvain (UCL)
The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.
Basic, translational and clinical pain research at the Institute of Neuroscience (IONS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute.
André Mouraux pain research EEG nociception letswave software analysis free matlab wavelets toolbox nocions
|Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.|
|The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.
|Letswave is a free toolbox to analyze electroencephalographic (EEG) and other neurophysiological signals, running in Matlab. As compared to existing signal processing toolboxes, emphasis is placed on intuitive and streamlined tools to process and visualize neurophysiological signals, with a shallow learning curve. The new version provides advanced scripting possibilities.|
Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity
Reliable EEG responses to the selective activation of C-fibre afferents using a temperature-controlled infrared laser stimulator in conjunction with an adaptive staircase algorithm
Jankovski A, Plaghki L, Mouraux A. Pain (2013); 154(9): 1578-87. [PDF]
Steyaert A, Lavand'homme P. Eur J Anaesthesiol (2013); 30(2):50-2.
Legrain V, Crombez G, Plaghki L, Mouraux A. Cortex (2013); 49(7):1922-34. [PDF]
Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial.
Forget P, Berlière M, van Maanen A, Duhoux FP, Machiels JP, Coulie PG, Bouche G, De Kock M; Ketorolac in Breast Cancer trial (KBCtrial) group. Med Hypotheses (2013); 81(4):707-12.
Prognostic value of olfactory bulb volume measurement for recovery in postinfectious and posttraumatic olfactory loss.
Rombaux P, Huart C, Deggouj N, Duprez T, Hummel T. Otolaryngol Head Neck Surg (2012); 147(6):1136-41.
Novelty is not enough: laser-evoked potentials are determined by stimulus saliency, not absolute novelty.
Ronga I, Valentini E, Mouraux A, Iannetti GD. J Neurophysiol (2013); 109(3):692-701. [PDF]
Nozaradan S, Peretz I, Mouraux A. J Neurosci (2012); 32(49):17572-81. [PDF]
Steady-state evoked potentials to study the processing of tactile and nociceptive somatosensory input in the human brain.
Colon E, Legrain V, Mouraux A. Neurophysiol Clin (2012); 42(5):315-23. [PDF]
Legrain V, Mancini F, Sambo CF, Torta DM, Ronga I, Valentini E. Neurophysiol Clin (2012); 42(5): 325-36. [PDF]
Estimation of intraepidermal fiber density by the detection rate of nociceptive laser stimuli in normal and pathological conditions
Mouraux A, Ragé M, Bragard D, Plaghki L. Neurophysiol Clin (2012); 42(5): 281-91. [PDF]
Predicting chronicity in acute back pain: validation of a French translation of the Örebro Musculoskeletal Pain Screening Questionnaire.
Nonclercq O, Berquin A. Ann Phys Rehabil Med (2012); 55(4):263-78.
Activating selectively and reliably nociceptive afferents with concentric electrode stimulation: yes we can, provided that low stimulus intensities are used
Legrain V, Mouraux A. Clin Neurophysiol (2012); 124(2): 424. [letter to the editor] [PDF]
Steyaert A, De Kock M. Curr Opin Anaesthesiol (2012); 25(5):584-8.
Automated single-trial assessment of laser-evoked potentials as an objective functional diagnostic tool for the nociceptive system
Hatem SM, Hu L, Ragé M, Gierasimowicz-Fontana A, Plaghki L, Bouhassira D, Attal N, Iannetti GD, Mouraux A. Clin Neurophysiol (2012); 123(12): 2437-45. [PDF]
Gamma-band oscillations in the primary somatosensory cortex - a direct and obligatory correlate of subjective pain intensity.
Zhang ZG, Lu H, Hung YS, Mouraux A, Iannetti GD. J Neurosci (2012) 32(22): 7429-38. [PDF]
Thermal detection thresholds of A-delta and C-fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin.
Churyukanov M, Plaghki L, Legrain V, Mouraux A. PLoS ONE (2012) 7(4): e35817. [PDF]
Van Damme S, Legrain V. Pain (2012); 153(6): 1226-1231.
Rombaux P, Huart C, Mouraux A. Rhinology (2012) 50(1): 13-21. [PDF]
Time-frequency analysis of chemosensory event-related potentials to characterize the cortical representation of odors in humans.
Huart C, Legrain V, Hummel T, Rombaux P, Mouraux A. PLoS ONE (2012) e33221. [PDF]
Adaptation visuo-motrice et représentations corporelles: de la négligence au syndrome douloureux régional complexe.
Jacquin-Courtois S, Legrain V, Sumitani JP, Muyauchi S, Rossetti Y. La Lettre de Médecine Physique et de Réadaptation (2012); 28: 93-8. [PDF]
Dyspnea-pain counter-irritation induced by inspiratory threshold loading: a laser evoked potentials study.
Bouvier G, La Violette L, Kindler F, Naccache L, Mouraux A, Similowski T, Morelot-Panzini C. J Appl Physiol (2012) 112(7):1166-73.
Dishabituation of laser-evoked EEG responses: dissecting the effect of certain and uncertain changes in stimulus spatial location.
Torta DM, Liang M, Valentini E, Mouraux A, Iannetti GD. Exp Brain Res (2012) 218(3): 361-72. [PDF]
Legrain V, Bultitude JH, De Paepe A, Rossetti Y. Pain (2012); 153: 948-951. [PDF]
Huart C, Meusel T, Gerber J, Duprez T, Rombaux P, Hummel T. AJNR Am J Neuroradiol (2011); 32(10):1911-4.
Colon E, Nozaradan S, Legrain V, Mouraux A. Neuroimage (2011); 60(1):571-581. [PDF]
Nozaradan S, Peretz I, Mouraux A. Neuroimage (2011); 60(1): 21-28. [PDF]
Taking into account latency, amplitude and morphology: improved estimation of single-trial ERPs by wavelet filtering and multiple linear regression
Hu L, Liang M, Mouraux A, Wise RG, Hu Y, Iannetti GD. J Neurophysiol (2011); 106(6): 3216-29. [PDF]
Nozaradan S, Peretz I, Missal M, Mouraux A. J Neurosci (2011) 31(28): 10234-40. [PDF]
Parallel processing of nociceptive and non-nociceptive somatosensory information in the human primary and secondary somatosensory cortices: evidence from dynamic causal modelling of fMRI data
Liang M, Mouraux A, Iannetti GD. J Neurosci (2011) 31(24): 8976-85. [PDF]