Caroline Huart

Caroline Huart

Post-doctorate researcher 

(FNRS clinicien chercheur postdoctorant)

Coordinators : Pr. P. Rombaux; Pr. A. Mouraux

The aim of our research project is to develop new methods for assessing the function of the olfactory system in humans (psychophysical assessment and electrophysiological assessment using chemosensory event-related brain potentials (CSERP)). CSERPs have an important disadvantage: the relatively weak signal-to-noise ratio of the recorded responses often limit the interpretation of the recorded responses. We thus developed new stimulation and analysis techniques to increase the signal-to-noise ratio of olfactory and trigeminal CSERPs. Finally, we are documenting the usefulness of chemosensory assessment for the diagnosis of pathologies associated with olfactory dysfunction, in particular, the differential diagnosis of mild cognitive impairment.

Clinician at the Dept. of Otorhinolaryngology of the Cliniques universitaires Saint Luc. 

The aim of our research project is to develop new methods for assessing the function of the olfactory system in humans (psychophysical assessment and electrophysiological assessment using chemosensory event-related brain potentials (CSERP)). CSERPs have an important disadvantage: the relatively weak signal-to-noise ratio of the recorded responses often limit the interpretation of the recorded responses. We thus developed new stimulation and analysis techniques to increase the signal-to-noise ratio of olfactory and trigeminal CSERPs. Finally, we are documenting the usefulness of chemosensory assessment for the diagnosis of pathologies associated with olfactory dysfunction, in particular, the differential diagnosis of mild cognitive impairment.

Publications

Physiologie, exploration et troubles de l'olfaction

Huart C, Mouraux A, Rombaux P. In : EMC en oto-rhinolaryngologie. (EMC, Ed.). Les traités EMC. Elsevier-Masson. 2016.

Exploration fonctionnelle et troubles du gout

Huart C, Mouraux A, Rombaux P. In : EMC en oto-rhinolaryngologie. (EMC, Ed.). Les traités EMC. Elsevier-Masson. 2016.

Unirhinal olfactory testing for the diagnostic workup of mild cognitive impairment

Huart C, Rombaux P, Gérard T, Hanseeuw B, Lhommel R, Quenon L, Ivanoiu A, Mouraux A. J Alzheimers Dis (2015); 47(1): 253-270. [PDF]

Effect of three-drug delivery modalities on olfactory function in chronic sinusitis

Reychler G, Colbrant C, Huart C, Le Guellec S, Vecellio L, Liistro G, Rombaux P. Laryngoscope (2015); 125(3): 549-55

Volume of olfactory bulb and depth of olfactory sulcus in 378 consecutive patients with olfactory loss

Hummel T, Urbig A, Huart C, Duprez T, Rombaux P. J Neurol (2015); 262(4):1046-51. [PDF]

Olfactory event-related potentials in infants

Schriever VA, Gois-Eanes M, Schuster B, Huart C, Hummel T. J Pediatr (2014); 165(2): 372-375. [PDF]

Non-sinonasal-related olfactory dysfunction: A cohort of 496 patients

Fonteyn S, Huart C, Deggouj N, Collet S, Eloy P, Rombaux P. Eur Ann Otorhinolaryngol Head Nech Dis. (2014); 131(2): 87-91.

Plasticity of the human olfactory system : the olfactory bulb.

Huart C, Rombaux P, Hummel T. Molecules (2013); 18(9): 11586-600.

Clinical usefulness and feasibility of time-frequency analysis of chemosensory event-related potentials

Huart C, Rombaux P, Hummel T, Mouraux A. Rhinology (2013); 51(3): 210-21. [PDF]

Prognostic value of olfactory bulb volume measurement for recovery in postinfectious and posttraumatic olfactory loss.

Rombaux P, Huart C, Deggouj N, Duprez T, Hummel T. Otolaryngol Head Neck Surg (2012); 147(6):1136-41.

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Posters

Enhancement of trigeminal chemosensory function in congenital anosmia and its contribution to the perception of odors.

Huart C, Mouraux A, Duprez T, Rombaux P. Spring Meeting of the SRB ORL. Brussels, Mar 2012.

Phase-locked and non phase-locked EEG responses elicited by intranasal nociceptive chemosensory stimulation to explore trigeminal function in humans

Huart C, Rombaux P, Mouraux A. Pain in Europe VII - 7th Congress of the European Federation of IASP Chapters (EFIC). Hamburg. Sept 2011.

The depth of the olfactory sulcus is an indicator of congenital anosmia.

Huart C, Meusel T, Gerber J, Duprez T, Rombaux P, Hummel T. Human Chemosensation 2010. Dresden, Dec. 2010.

Awards

Best lecture in Rhinology 2015 during the meeting of the Belgian ORL society

Boute C, Huart C, Hummel T, Krahling C, Konstantinidis I, Mouraux A, Rombaux P. "Develoment of a new psychophysical method to assess intranasal trigeminal chemosensory function ; preliminary results » 

GlaxoSmithKline Poster's award in Rhinology 2012

Enhancement of trigeminal chemosensory function in congenital anosmia and its contribution to the perception of odors. Huart C, Mouraux A, Duprez T, Rombaux P. Spring Meeting of the SRB ORL. Brussels, Mar 2012.

Research Prize 2012 of the European Rhinologic Society

Huart C (2012; supervisors: A. Mouraux, P. Rombaux)

GlaxoSmithKline Award in Rhinology 2011

Huart C, Mensel T, Gerber Th, Duprez Th, Rombaux Ph, Hummel T. (2011; supervisors: Mouraux A & Rombaux P). Prize award by the Société Royale Belge d'ORL et de Chirurgie Cervico-faciale / Koninklijke Belgische Vereniging voor ORL for the work entitled "The depth of olfactory sulcus is an indication of congenital anosmia" C. Huart, T. Mensel, J. Gerber, Th. Duprez, Ph. Rombaux, Th. Hummel.

Research projects

Novel approaches to assess olfactory function and dysfunction in humans

Investigators : Caroline Huart, Philippe Rombaux, André Mouraux. Compared to other sensory modalities, the physiology and pathophysiology of olfaction remains poorly explored in humans. Yet, olfactory disorders are common in the general population, affecting up to 20% of the population. Over the...