Giulia Liberati

Giulia Liberati

Postdoctorate researcher (FNRS chargé de recherches)

Coordinator : Pr. A. Mouraux

My project investigates the role of the primary (S1) and secondary (S2) somatosensory cortices, the insula, and the anterior cingulate cortex (ACC) in human pain perception. To this end, I use intracerebral EEG recordings performed in patients for the presurgical evaluation of intractable epilepsy, combined with advanced signal-processing methods.


Gamma-band oscillations preferential for nociception can be recorded in the human insula

Liberati G, Klöcker A, Algoet M, Mulders D, Safronova MM, Ferrao Santos S, Vaz JG, Raftopoulos C, Mouraux A. Cerebral Cortex (2017); in press. [PDF]

Nociceptive local field potentials recorded from the human insula are not specific for nociception

Liberati G, Klocker A, Safronova MM, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A. PLoS Biology (2016); 14(1):e1002345. [PDF]

Questioning the dichotomy between vegetative state and minimally conscious state: a review of the statistical evidence.

Liberati G, Hünefeldt T, Olivetti Belardinelli M. Front Hum Neurosci (2014); 8:865

Insula and inferior frontal triangularis activations distinguish between conditioned brain responses using emotional sounds for basic BCI communication.

van der Heiden L, Liberati G, Sitaram R, Kim S, Jaśkowski P, Raffone A, Olivetti Belardinelli M, Birbaumer N, Veit R. Front Behav Neurosci (2014); 8:247

Brain-machine interface in chronic stroke rehabilitation: a controlled study.

Ramos-Murguialday A, Broetz D, Rea M, Läer L, Yilmaz O, Brasil FL, Liberati G, Curado MR, Garcia-Cossio E, Vyziotis A, Cho W, Agostini M, Soares E, Soekadar S, Caria A, Cohen LG, Birbaumer N. Ann Neurol (2013); 74(1): 100-8.

Toward a brain-computer interface for Alzheimer's disease patients by combining classical conditioning and brain state classification.

Liberati G, Dalboni da Rocha JL, van der Heiden L, Raffone A, Birbaumer N, Olivetti Belardinelli M, Sitaram R.
J Alzheimers Dis. (2012);31 Suppl 3:S211-20.

Cognitive reserve and its implications for rehabilitation and Alzheimer's disease.

Liberati G, Raffone A, Olivetti Belardinelli M. Cogn Process (2012);13(1):1-12.        


Pain-related gamma-band oscillations elicited in the human insula are modulated by epileptic acitivity

Ferrao Santos S, Liberati G, Klöcker A, Safronova MM, El Tahry R, Ribeiro Vaz JG, Raftopoulos C, Mouraux A. 16th World Congress on Pain, Yokohama (Japan), Sept. 2016.

The insular cortex displays pain-specific gamma-band oscillations, possibly disrupted by insular epileptiform activity

Ferrao-Santos S, Liberati G, Klöcker A, Safronova MM, El Tahry R, Ribeiro Vaz JG, Raftopoulos C, Mouraux A. 69th Annual Meeting of the American Epilepsy Society. Philadelphia (USA), Dec 2015.

Research projects

Intracerebral EEG recordings to investigate the role of the insula in nociception

Investigators : Giulia Liberati, Susana Ferrao Santos, André Mouraux. A widely accepted notion is that one particular region of the “pain matrix”, the insula, plays a specific role in the perception of pain, and the activity recorded from this region is often considered as an objective signature of...

Questioning the functional significance of the “pain matrix”

Investigators : André Mouraux, Giulia Liberati, Elisabeth Colon. Neuroimaging and neurophysiological studies have shown that transient nociceptive stimuli elicit responses in an extensive cortical network including somatosensory, insular and cingulate areas, as well as frontal and parietal areas. A...