Lieve Filbrich

Lieve Filbrich

PhD student (FNRS aspirant)
Promoter : Pr. V. Legrain

Adequately responding to a painful stimulus requires knowing where pain is localized on the body, but also where the cause of pain is localized in the external world. This involves for the brain to coordinate the somatotopic representation of the body and the representations of the space around the body. According to a recent theory, the spatial localization of pain depends on a cortical mapping system that integrates nociceptive (localization of the salient and threatening stimulus on the body), proprioceptive (localization of the limbs in external space) and visual information (localization of the cause/source of pain in the external world) into a multimodal and peripersonal representation of the body and the space nearby. The aim of the present project is to strengthen this theory by investigating, in patients suffering from complex regional pain syndrome (CRPS), how pain in one limb affects the representation of the space surrounding the body. More specifically, using behavioral measures (temporal order judgment tasks), we will characterize the “neglect-like” deficits of CRPS patients in perceiving the spatial location of visual stimuli occurring close to the body. Findings will help to understand how pain is integrated in a peripersonal representation of the body and the space nearby. They could also have an important impact on the understanding and the rehabilitation of chronic pain.

Publications

Investigating peri-limb interaction between nociception and vision using spatial depth.

Vanderclausen C, Filbrich L, Alamia A, Legrain V. Neurosci Lett (2017); in press.

Intense pain influences the cortical processing of visual stimuli projected onto the sensitized skin

Torta DM, van den Broeke EN, Filbrich L, Jacob B, Lambert J, Mouraux A. Pain (2017); 158(4):691-697. [PDF]

Using temporal order judgments to investigate attention bias towards pain and threat-related information. Methodological and theoretical issues

Filbrich L, Torta DM, Vanderclausen C, Azanon E, Legrain V. Consciousness and Cognition (2016); 41:135-8. [PDF]

Posters

Attention does not mediate the enhanced processing of non-nociceptive sensory stimuli presented onto the sensitized skin

Torta D, Filbrich L, van den Broeke E, Legrain V. 16th World Congress on Pain, Yokohama (Japan), Sept. 2016.

Nociceptive extinction in response to double stimulation

Legrain V, Blandiaux S, Farnè A, Plaghki L, Filbrich L. 16th World Congress on Pain, Yokohama (Japan), Sept. 2016.

Does CRPS Impair the Perception of Somatosensory and Non-Somatosensory Stimuli?

Filbrich L, Alamia A, Verfaille C, Barbier O, Libouton X, FraselleV, Mouraux D, Berquin A,  Legrain V. 16th World Congress on Pain, Yokohama (Japan), Sept. 2016.

Cross-modal interactions between pain and vision: enhanced responses to visual stimuli applied in an area of secondary hyperalgesia

Torta DM, Filbrich L, Lambert J, van den Broeke EN, Mouraux A 9th EFIC congress, Vienna, 2nd  -5th September,  2015.

Shifting attention between the space of the body and external space. Electrophysiological correlates of visual-nociceptive crossmodal spatial attention

Filbrich, L., Favril, L., Mouraux, A., Sambo, C.F., Legrain V. 30th International Congress on Clinical Neurophysiology (ICCN), Berlin, Germany, March 19-23 2014.

Research projects

Temporal order judgment tasks to characterize the “neglect-like” deficits of CRPS

Investigators : Lieve Filbrich, Valery Legrain. Adequately responding to a painful stimulus requires knowing where pain is localized on the body, but also where the cause of pain is localized in the external world. This involves for the brain to coordinate the somatotopic representation of the body...