TMS and tDCS combined with EEG and fMRI to characterize the organization and interdependencies between brain areas involved in nociception

TMS and tDCS combined with EEG and fMRI to characterize the organization and interdependencies between brain areas involved in nociception

Investigators : Cédric Lenoir, Maxime Algoet, Meng Liang, Diana Torta, André Mouraux.

In this project, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) is combined with EEG and functional MRI to characterize the organization and interdependencies between different brain areas involved in processing somatosensory and nociceptive inputs and in the perception of pain in humans. Two approaches are used. In the first approach, brain responses to nociceptive stimuli are sampled using EEG and fMRI, before and after modulating the excitability of a specific brain region using repetitive TMS or tDCS. In the second approach, brain responses elicited by a single pulse of TMS applied over a given brain region are sampled using online EEG or FMRI, such as to characterize changes in functional connectivity related to central sensitization.