Emanuel van den Broeke - postdoc (FRC)

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The main objective of my research is to study pain - or nociception- induced central nervous system plasticity. Currently, my studies are focused on characterizing changes in nociceptive pathways that lead or contribute to hyperalgesia, and I am, thereby, particularly interested in the phenomenon of "central sensitization"; the increase responsiveness of nociceptive neurons in the central nervous system that generates widespread hyperalgesia ("secondary hyperalgesia").

Group members

Publications

2021

High-frequency electrical stimulation of cutaneous nociceptors differentially affects pain perception elicited by homotopic and heterotopic electrical stimuli

J Neurophysiol

van den Broeke EN, Urdi M, Mouraux A, Biurrun Manresa J, Torta DM

126(4):1038-1044.

2020

Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study

Royal Society Open Science

van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM

8(1):200830.

2020

Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

10: 22319

2020

Central sensitization of nociceptive pathways demonstrated by robot-controlled pinprick-evoked brain potentials

Clinical Neurophysiology

van den Broeke EN, de Hemptinne P, Mercken M, Torta DM, Lambert J, Mouraux A.

131(10):2491-2498.

2020

Within- and between-session reliability of secondary hyperalgesia induced by electrical high-frequency stimulation

European Journal of Pain

Cayrol T, Lebleu J, Mouraux A, Roussel N, Pitance L, van den Broeke E.

24(8):1585-1597.

2020

A highly cognitive demanding working memory task may prevent the development of nociceptive hypersensitivity

Pain

Torta DME, De Laurentis M, Eichin KN, Von Leupoldt A, van den Broeke EN, Vlaeyen J.

161(7):1459-1469.

2020

Burst-like conditioning electrical stimulation is more efficacious than continuous stimulation for inducing secondary hyperalgesia in humans

Journal of Neurophysiology

Gousset S, Mouraux A, van den Broeke EN.

123(1):323-328

2020

The focus of spatial attention during the induction of central sensitization can modulate the subsequent development of secondary hyperalgesia

Cortex

Filbrich L, van den Broeke E, Legrain V, Mouraux .

124:193-203

2019

Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation

Journal of Neurophysiology

van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.

122(3):994-1001

2019

Central sensitization in humans: Popular phrase or useful concept?

Journal of Psychosomatic Research

van den Broeke EN, Van den Bergh O.

119:51-52

2019

Central sensitization increases the pupil dilation elicited by mechanical pinprick stimulation

Journal of Neurophysiology

van den Broeke EN, Hartgerink DM, Butler J, Lambert J, Mouraux A.

121(5):1621-1632

2018

No evidence of widespread mechanical pressure hyperalgesia after experimentally-induced central sensitization via skin nociceptors

Pain Reports

Cayrol T, Pitance L, Roussel N, Mouraux A, van den Broeke EN.

3(6): e691

2018

Central sensitization and pain hypersensitivity: some critical considerations

F1000 Research

van den Broeke EN.

2018

High frequency electrical stimulation induces a long-lasting enhancement of event-related potentials but does not change the perception elicited by intra-epidermal electrical stimuli delivered to the area of increased mechanical pinprick sensitivity

PLoS One

Manresa JB, Andersen OK, Mouraux A, van den Broeke EN.

13(9):e0203365

2018

Quickly-responding C-fiber nociceptors contribute to heat hypersensitivity in the area of secondary hyperalgesia

Journal of Physiology

Lenoir C, Plaghki L, Mouraux A, van den Broeke EN.

in press