Emanuel van den Broeke - postdoc (FRC)
The main objective of my research is to study pain - or nociception- induced central nervous system plasticity. Currently, my studies are focused on characterizing changes in nociceptive pathways that lead or contribute to hyperalgesia, and I am, thereby, particularly interested in the phenomenon of "central sensitization"; the increase responsiveness of nociceptive neurons in the central nervous system that generates widespread hyperalgesia ("secondary hyperalgesia").
Group members
Publications
2020
Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study
Royal Society Open Science
van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM
in press.
2020
Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
Nature: Scientific Reports
Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
10: 22319
2020
Central sensitization of nociceptive pathways demonstrated by robot-controlled pinprick-evoked brain potentials
Clinical Neurophysiology
van den Broeke EN, de Hemptinne P, Mercken M, Torta DM, Lambert J, Mouraux A.
131(10):2491-2498.
2020
Within- and between-session reliability of secondary hyperalgesia induced by electrical high-frequency stimulation
European Journal of Pain
Cayrol T, Lebleu J, Mouraux A, Roussel N, Pitance L, van den Broeke E.
24(8):1585-1597.
2020
A highly cognitive demanding working memory task may prevent the development of nociceptive hypersensitivity
Pain
Torta DME, De Laurentis M, Eichin KN, Von Leupoldt A, van den Broeke EN, Vlaeyen J.
161(7):1459-1469.
2020
Burst-like conditioning electrical stimulation is more efficacious than continuous stimulation for inducing secondary hyperalgesia in humans
Journal of Neurophysiology
Gousset S, Mouraux A, van den Broeke EN.
123(1):323-328
2020
The focus of spatial attention during the induction of central sensitization can modulate the subsequent development of secondary hyperalgesia
Cortex
Filbrich L, van den Broeke E, Legrain V, Mouraux .
124:193-203
2019
Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation
Journal of Neurophysiology
van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.
122(3):994-1001
2019
Central sensitization in humans: Popular phrase or useful concept?
Journal of Psychosomatic Research
van den Broeke EN, Van den Bergh O.
119:51-52
2019
Central sensitization increases the pupil dilation elicited by mechanical pinprick stimulation
Journal of Neurophysiology
van den Broeke EN, Hartgerink DM, Butler J, Lambert J, Mouraux A.
121(5):1621-1632
2018
No evidence of widespread mechanical pressure hyperalgesia after experimentally-induced central sensitization via skin nociceptors
Pain Reports
Cayrol T, Pitance L, Roussel N, Mouraux A, van den Broeke EN.
3(6): e691
2018
Central sensitization and pain hypersensitivity: some critical considerations
F1000 Research
van den Broeke EN.
​
2018
High frequency electrical stimulation induces a long-lasting enhancement of event-related potentials but does not change the perception elicited by intra-epidermal electrical stimuli delivered to the area of increased mechanical pinprick sensitivity
PLoS One
Manresa JB, Andersen OK, Mouraux A, van den Broeke EN.
13(9):e0203365
2018
Quickly-responding C-fiber nociceptors contribute to heat hypersensitivity in the area of secondary hyperalgesia
Journal of Physiology
Lenoir C, Plaghki L, Mouraux A, van den Broeke EN.
596(18):4443-4455.
2018
Central sensitization: explanation or phenomenon?
Clinical Psychological Science
van den Broeke EN, Torta DM, Van den Bergh O.
in press