Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN

Cool-evoked brain potentials (CEPs)

A few studies showed that brisk innocuous cooling of the skin can be used to elicit CEPs related to the activation of cool-sensitive Adelta fibers [34, 41]. However, the responses reported in these previous studies had a low signal-to-noise ratio (SNR), probably due to the limited cooling ramps achieved by the cooling devices, leading to poor time-locking of the activity generatedin cool-sensitive afferents. Recently, we recorded CEPs using a thermode prototype developed by Pr A. Dufour (Strasbourg University) [42]. The device is able to generate very steep cooling ramps of up to 300°C/s. Brisk innocuous cooling of the skin using such ramps elicit CEPs with a high SNR, opening new possibilities to study cool and cold perception in humans.

Mulders D, de Bodt C, Lejeune N, Mouraux A, Verleysen M. In: Deville Y, Gannot S, Mason R, Plumbley M, Ward D (eds). Latent Variable Analysis and Signal Separation LVA/ICA 2018; Lecture notes in Computer Science, vol 10891. Springer. [PDF]

De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A. 

Clin Neurophysiol (2018); 129(5):1011-1019. [PDF]

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Researchers involved :

  • André Mouraux

  • Roxane Dekeyser

  • Arthur Courtin