Alexandre Stouffs - PhD student (IMI2 PAINCARE)


My PhD is conducted in the framework of a large-scale Innovative Medicines Initiative (IMI PAIN-CARE; project, subtopic BioPain. The aim of this subtopic is to identify and validate a number of functional biomarkers based on non-invasive measures of neural activity (peripheral measures of nerve excitability, spinal and brainstem reflexes, measures of brain activity using electroencephalography [EEG] and functional magnetic resonance imaging [MRI] that can be used in humans to assess the effects of a given drug on the nociceptive system. If successful, these biomarkers would be used in future studies for the early stages of the pharmacological development of novel treatments for pain, and back-translated to animal models.



Mouraux A, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Di Stefano G, Finnerup NB, Garcia-Larrea L, Goetz M, Kostenko A, Pelz B, Pogatzki-Zahn E, Schubart K, Stouffs A, Truini A, Tracey I, Troconiz IF, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Treede RD.


IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).


European Journal of Pain

Quesada C, Kostenko A, Ho I, Leone C, Nochi Z, Stouffs A, Wittayer M, Caspani O, Finnerup NB, Mouraux A, Pickering G, Tracey I, Truini A, Treede RD, Garcia-Larrea L.


Human surrogate models of central sensitization: a critical review and practical guide


Royal Society Open Science

van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM


Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study


Journal of Neurophysiology

van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.


Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation


Douleur et Analgésie

Stouffs A, Lebrun L, Mouraux A.

31(4): 230

IMI-PAINCARE, BIOPAIN : validation chez l'homme de nouveaux biomarqueurs fonctionnels pour le développement pharmacologique de traitements de la douleur



Journal of Clinical Monitoring and Computing

Stouffs A, Ibsen A, Jamart J, Dubois V, Dubois PE.

32(5): 965-966

Philips Intellivue NMT module: variability of initial measurements



Acta Anaesthesiologica Belgica

Stouffs A, Scholtes JL.

67(4): 197-199

Intraoperatively diagnosed tracheal tear during a parathyroidectomy with previously undiagnosed tracheomalacia: a case report