André Mouraux - Principal investigator (IONS/COSY)

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Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

Publications

Trials

Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.

23(1):163.

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

2022

J Neural Eng

Su S, Chai G, Meng J, Sheng X, Mouraux A, Zhu X.

19(1).

Towards optimizing the non-invasive sensory feedback interfaces in a neural prosthetic control

2022

J Pain

Courtin AS, Mouraux A

in press.

Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin

2021

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Neurophysiol Clin

Di Pietro G, Di Stefano G, Leone C, Di Lionardo A, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Valeriani M, Truini A.

S0987-7053(21)00088-5.

The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons

2021

Scientific Reports

Di Lionardo A, Di Stefano G, Leone C, Di Pietro G, Sgro E, Malara E, Cosentino C, Mollica C, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Treede RD, Phillips KG, Valeriani M, Truini A.

11(1):20838.

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

2021

Neurotherapeutics

Vespa S, Heyse J, Stumpp L, Liberati G, Ferrao Santos S, Rooijakkers H, Nonclercq A, Mouraux A, van Mierlo P, El Tahry R.

in press.

Vagus Nerve Stimulation elicits sleep EEG desynchronization and network changes in responder patients in epilepsy

2021

Clin Neurophysiol

Leone C, Di Lionardo A, Di Pietro G, Di Stefano G, Falco P, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Truini A.

32(12):2989-2995.

How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex.

2021

J Neurophysiol

van den Broeke EN, Urdi M, Mouraux A, Biurrun Manresa J, Torta DM

126(4):1038-1044.

High-frequency electrical stimulation of cutaneous nociceptors differentially affects pain perception elicited by homotopic and heterotopic electrical stimuli

2021

Trials

Mouraux A, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Di Stefano G, Finnerup NB, Garcia-Larrea L, Goetz M, Kostenko A, Pelz B, Pogatzki-Zahn E, Schubart K, Stouffs A, Truini A, Tracey I, Troconiz IF, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Treede RD.

22(1):404.

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).

2021

NPJ Microgravity

Salatino A, Iacono C, Gammeri R, Chiadò ST, Lambert J, Sulcova D, Mouraux A, George MS, Roberts DR, Berti A, Ricci R.

7(1):29.

Zero gravity induced by parabolic flight enhances automatic capture and weakens voluntary maintenance of visuospatial attention.

2021

PLoS One

Dumoulin M, Liberati G, Mouraux A, Santos SF, El Tahry R.

16(7):e0254480.

Transcutaneous auricular VNS applied to experimental pain: A paired behavioral and EEG study using thermonociceptive CO2 laser.

2021

J Gambl Stud

Ninghetto M, Belli F, Nobili M, Mouraux A, Ricci R.

in press.

Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder.

2021

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European Journal of Pain

Quesada C, Kostenko A, Ho I, Leone C, Nochi Z, Stouffs A, Wittayer M, Caspani O, Finnerup NB, Mouraux A, Pickering G, Tracey I, Truini A, Treede RD, Garcia-Larrea L.

25(7):1389-1428.

Human surrogate models of central sensitization: a critical review and practical guide

2021

European Journal of Pain

Mouraux A, Bannister K, Becker S, Finn DP, Pickering G, Pogatzki-Zahn E, Graven-Nielsen T.

in press.

Challenges and opportunities in translational pain research - an opinion paper of the working group on translational pain research of the European Pain Federation (EFIC)

2021

Royal Society Open Science

van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM

8(1):200830.

Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study

2020