André Mouraux - Principal investigator (IONS/COSY)

Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.
Publications
2026
A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers
Clin Neurophysiol
Leone CM, Di Pietro G, Di Stefano G, Quesada C, Salameh C, Perchet C, Garcia-Larrea L, Mouraux A, Lebrun L, Gousset S, Möller-Grell N, Kostenko A, Finnerup NB, Caspani O, Bo J, Genser B, Treede RD, Truini A
in press
2026
Extracting electroencephalogram aperiodic activity from intraoperative frontal α-band power does not modify its association with delirium after cardiac surgery
Eur J Anaesthesiol
Khalifa C, Momeni M, Renard A, Demanet N, Lenoir C, Mouraux A
in press
2026
Normative Values for Contact Heat and Cold Evoked Potentials
Eur J Pain
Foolchand Y, Kuzminova A, Louis MH, Courtin A, Dessart P, Mouraux A, Hatem SM
30(1):e70196.
2025
Global Poorer Olfaction, Frailty and Postoperative Adverse Outcomes: Exploring Their Interplay in a Prospective Cohort of Older Adults Undergoing Elective Surgery
Clin Interv Aging
Van Regemorter V, Momeni M, Bouhours J, Mouraux A, Huart C
20:2567-2578.
2025
Perceptual learning can improve nociceptive directional discrimination
Eur J Neurosci
Rujoie A, Andersen OK, Mouraux A, Frahm KS
in press
2025
Electrical Spinal Imaging (ESI): Non invasive, high-resolution mapping of spinal cord activity
PLOS Biology
Gabrieli G, Somervail R, Mouraux A, Leandri M, Haggard P, Iannetti GD
in press
2025
Emerging role of electroencephalographic aperiodic activity in anesthesia: a narrative review
Anesthesiology
Demanet N, Khalifa C, Momeni M, Mouraux A, Lenoir C
in press
2025
Interindividual variations in peak alpha frequency do not predict the magnitude or extent of secondary hyperalgesia induced by high-frequency stimulation
J Neurophysiol
Lebrun L, Ricci G, Courtin A, van den Broeke EN, Lenoir C, Mouraux A
in press
Effects of lacosamide, pregabalin, and tapentadol on peripheral nerve excitability: A randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects
Anesthesiology
Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo D, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Jiang B, Rong C, Mouraux A, Pelz B, Phillips KG, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Treede RD, Tankisi H, Finnerup NB
in press
2025
Boundaries of Tactile Acuity when Exploring Surfaces
Surface Topography: Metrology and Properties
Fradin J, Dione M, Mouraux A, Ackerley R, Gueorguiev D
in press