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André Mouraux - Principal investigator (IONS/COSY)

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Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

Publications

2026

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A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers

Clin Neurophysiol

Leone CM, Di Pietro G, Di Stefano G, Quesada C, Salameh C, Perchet C, Garcia-Larrea L, Mouraux A, Lebrun L, Gousset S, Möller-Grell N, Kostenko A, Finnerup NB, Caspani O, Bo J, Genser B, Treede RD, Truini A

in press

2026

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Extracting electroencephalogram aperiodic activity from intraoperative frontal α-band power does not modify its association with delirium after cardiac surgery

Eur J Anaesthesiol

Khalifa C, Momeni M, Renard A, Demanet N, Lenoir C, Mouraux A

in press

2026

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Normative Values for Contact Heat and Cold Evoked Potentials

Eur J Pain

Foolchand Y, Kuzminova A, Louis MH, Courtin A, Dessart P, Mouraux A, Hatem SM

30(1):e70196.

2025

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Global Poorer Olfaction, Frailty and Postoperative Adverse Outcomes: Exploring Their Interplay in a Prospective Cohort of Older Adults Undergoing Elective Surgery

Clin Interv Aging

Van Regemorter V, Momeni M, Bouhours J, Mouraux A, Huart C

20:2567-2578.

2025

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Perceptual learning can improve nociceptive directional discrimination

Eur J Neurosci

Rujoie A, Andersen OK, Mouraux A, Frahm KS

in press

2025

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Electrical Spinal Imaging (ESI): Non invasive, high-resolution mapping of spinal cord activity

PLOS Biology

Gabrieli G, Somervail R, Mouraux A, Leandri M, Haggard P, Iannetti GD

in press

2025

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Emerging role of electroencephalographic aperiodic activity in anesthesia: a narrative review

Anesthesiology

Demanet N, Khalifa C, Momeni M, Mouraux A, Lenoir C

in press

2025

Neural correlates underlying high-frequency stimulation-induced secondary hyperalgesia in humans

Pain Reports

Clarke S, Wanigasekera V, Rogers R, Caspani O, Mouraux A, Fardo F, Finnerup NB, Treede RD, Tracey I.

10(6):e1342.

2025

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Interindividual variations in peak alpha frequency do not predict the magnitude or extent of secondary hyperalgesia induced by high-frequency stimulation

J Neurophysiol

Lebrun L, Ricci G, Courtin A, van den Broeke EN, Lenoir C, Mouraux A

in press

2024

Complex regional pain syndrome evolution is determined by both biological and psychosocial factors: a 1-year prospective observational study

Pain

Louis MH, Legrain V, Aron V, Filbrich L, Mouraux A, Henrard S, Guillaume L, Mouraux D, Barbier O, Libouton X, Berquin A.

in press

2025

Multisensory impact of visual stimuli on detection thresholds of thermo-nociceptive inputs conveyed by A-delta and C fibers

Behav Brain Res

Manfron L, Filbrich L, Della Porta D, Mouraux A, Legrain V.

496:115846.

2025

Effects of lacosamide, pregabalin, and tapentadol on peripheral nerve excitability: A randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects

Anesthesiology

Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo D, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Jiang B, Rong C, Mouraux A, Pelz B, Phillips KG, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Treede RD, Tankisi H, Finnerup NB

in press

2025

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Boundaries of Tactile Acuity when Exploring Surfaces

Surface Topography: Metrology and Properties

Fradin J, Dione M, Mouraux A, Ackerley R, Gueorguiev D

in press

2025

Navigating the biopsychosocial landscape: A systematic review on the association between social support and chronic pain

PLoS One

Rinaudo CM, Van de Velde M, Steyaert A, Mouraux A

20(4):e0321750.

2025

Repeated exposure to cutaneous high-frequency electrical stimulation prolongs the time course of secondary hyperalgesia

J Neurophysiol

Lebrun L, Stouffs A, Hermans E, van den Broeke E, Leone CM, Caspani O, Truini A, Garcia-Larrea L, Treede RD, Mouraux A.

in press

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

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