André Mouraux - Principal investigator (IONS/COSY)

Group : 

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Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

Publications

2022

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Characterization of vagus nerve stimulation-induced pupillary responses in epileptic patients

Brain Stimulation

Vespa S, Stumpp L, Liberati G, Delbeke J, Nonclercq A, Mouraux A, El Tahry R

in press.

2022

Investigating the Origin of TMS-evoked Brain Potentials Using Topographic Analysis.

Brain Topography

Sulcova D, Salatino A, Ivanoiu A, Mouraux A.

in press.

2022

No evidence for an effect of selective spatial attention on the development of secondary hyperalgesia: a replication study

Front Hum Neurosci

Della Porta D, Vila ML, Kuzminova A, Filbrich L, Mouraux A, Legrain V.

in press.

2022

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Chronic temporomandibular disorders are associated with higher susceptibility to developing central sensitization: a case-control study

Pain

Cayrol T, van den Broeke EN, Gerard E, Meeus M, Mouraux A, Roussel N, Pitance L.

in press.

2022

Olfactory dysfunction predicts frailty and poor postoperative outcome in older patients scheduled for elective non-cardiac surgery

J Nutr Health Aging

Van Regemorter V, Dollase J, Coulie R, Stouffs AD, de Saint-Hubert M, Mouraux A, Huart C.

in press.

2022

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Trials

Leone C, Di Stefano G, Di Pietro G, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Finnerup NB, Garcia-Larrea L, Li T, Goetz M, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Tracey I, Troconiz IF, Van Niel H, Hernandez JMV, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Truini A, Treede RD.

23(1):739.

2022

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development

Int J Mol Sci

van Niel J, Bloms-Funke P, Caspani O, Cendros JM, Garcia-Larrea L, Truini A, Tracey I, Chapman SC, Marco-Ariño N, Troconiz IF, Phillips K, Finnerup NB, Mouraux A* and Treede RD

23, 8295.

2022

Multichannel transcranial direct current stimulation over the left dorsolateral prefrontal cortex may modulate the induction of secondary hyperalgesia, a double-blinded cross-over study in healthy volunteers.

PLoS One

Steyaert A, Lenoir C, Lavand'homme P, van den Broeke EN, Mouraux A.

17(6):e0270047.

2022

Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: A systematic review of observational studies with meta-analysis

J Oral Rehabil

Cayrol T, Meeus M, Aron V, Gatto C, Mouraux A, Roussel NA, Sallaz L, van den Broeke EN, Pitance L.

49(6):654-670.

2022

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Trials

Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.

23(1):163.

2022

Towards optimizing the non-invasive sensory feedback interfaces in a neural prosthetic control

J Neural Eng

Su S, Chai G, Meng J, Sheng X, Mouraux A, Zhu X.

19(1).

2022

Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin

J Pain

Courtin AS, Mouraux A

23(5):754-771.

2021

The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons

Neurophysiol Clin

Di Pietro G, Di Stefano G, Leone C, Di Lionardo A, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Valeriani M, Truini A.

S0987-7053(21)00088-5.

2021

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

Scientific Reports

Di Lionardo A, Di Stefano G, Leone C, Di Pietro G, Sgro E, Malara E, Cosentino C, Mollica C, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Treede RD, Phillips KG, Valeriani M, Truini A.

11(1):20838.

2021

Vagus Nerve Stimulation elicits sleep EEG desynchronization and network changes in responder patients in epilepsy

Neurotherapeutics

Vespa S, Heyse J, Stumpp L, Liberati G, Ferrao Santos S, Rooijakkers H, Nonclercq A, Mouraux A, van Mierlo P, El Tahry R.

18(4):2623-2638.