Roberta Gualdani - Principal Investigator

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My research project involves looking for recurrent TRP ion channel mutations in patients suffering from severe chronic pain, in order to understand whether there is a genetic predisposition to the development of the pain conditions, and to develop personalized therapies to normalize the activity of the mutant channels. To this end, I combine the most advanced state-of-the-art techniques for the biophysical and pharmacological study of ion channels, including electrophysiology, fluorescence spectroscopy, biochemistry, structural modelling. I have also a wide experience in ion channel drug discovery and in the development of genetically modified mouse models for in vivo experiments.

Publications

2022

A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons

Proc Natl Acad Sci U S A.

Gualdani R, Gailly P, Yuan JH, Yerna X, Di Stefano G, Truini A, Cruccu G, Dib-Hajj SD, Waxman SG.

119(38):e2119630119.

2022

Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors.

Pain

Latragna A, Sabaté San José A, Tsimpos P, Vermeiren S, Gualdani R, Chakrabarti S, Callejo G, Desiderio S, Shomroni O, Sitte M, Kricha S, Luypaert M, Vanhollebeke B, Laumet G, Salinas G, Smith ESJ, Ris L, Bellefroid EJ.

163(8):e927-e941.

2021

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Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission

Sci Rep

Kreis A, Desloovere J, Suelves N, Pierrot N, Yerna X, Issa F, Schakman O, Gualdani R, de Clippele M, Tajeddine N, Kienlen-Campard P, Raedt R, Octave JN, Gailly P.

11(1):17600.

2021

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Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies

Pharmacol Rep

Cavalluzzi MM, Budriesi R, De Salvia MA, Quintieri L, Piarulli M, Milani G, Gualdani R, Micucci M, Corazza I, Rosato A, Viale M, Caputo L, Franchini C, Lentini G.

73(1):172-184.

2021

Trigeminal Neuralgia TRPM8 Mutation: Enhanced Activation, Basal [Ca2+]i and Menthol Response

Neurol Genet

Gualdani R, Yuan JH, Effraim PR, Di Stefano G, Truini A, Cruccu G, Dib-Hajj SD, Gailly P, Waxman SG.

7(1):e550.

2020

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Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design

Drug Discov Today

Cavalluzzi MM, Imbrici P, Gualdani R, Stefanachi A, Mangiatordi GF, Lentini G, Nicolotti O.

25(2):344-366.

2020

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Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release

eNeuro

Opsomer R, Contino S, Perrin F, Gualdani R, Tasiaux B, Doyen P, Vergouts M, Vrancx C, Doshina A, Pierrot N, Octave JN, Gailly P, Stanga S, Kienlen-Campard P.

7(3):ENEURO.0322-19.2020.

2020

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Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction

Int J Mol Sci

Tajeddine N, Tissir F, Gualdani R, Gailly P.

21(5):1712.

2020

How TRPC Channels Modulate Hippocampal Function

Int J Mol Sci

Gualdani R, Gailly P.

21(11):3915.

2020

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Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells

Sci Signal

Gualdani R, Seghers F, Yerna X, Schakman O, Tajeddine N, Achouri Y, Tissir F, Devuyst O, Gailly P.

3(653):eabc6967.

2019

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Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma

Cancers (Basel)

Gualdani R, de Clippele M, Ratbi I, Gailly P, Tajeddine N.

11(3):430.

2019

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Superparamagnetic iron oxide nanoparticles (SPIONs) modulate hERG ion channel activity

Nanotoxicology

Gualdani R, Guerrini A, Fantechi E, Tadini-Buoninsegni F, Moncelli MR, Sangregorio C.

13(9):1197-1209.

2018

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Drug Interactions With the Ca2+-ATPase From Sarco(Endo)Plasmic Reticulum (SERCA)

Front Mol Biosci

Tadini-Buoninsegni F, Smeazzetto S, Gualdani R, Moncelli MR.

5:36.

2018

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Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole

Cell Physiol Biochem

Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A, Lentini G.

45(6):2233-2245.

2018

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Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory

Front Cell Neurosci

Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F, Gailly P.

12:318.