NOCIONS all publications
NOCIONS all publications
Alexandre Stouffs - PhD student (IMI2 PAINCARE)
Group :
André Mouraux
My PhD is conducted in the framework of a large-scale Innovative Medicines Initiative (IMI PAIN-CARE; https://www.imi-paincare.eu) project, subtopic BioPain. The aim of this subtopic is to identify and validate a number of functional biomarkers based on non-invasive measures of neural activity (peripheral measures of nerve excitability, spinal and brainstem reflexes, measures of brain activity using electroencephalography [EEG] and functional magnetic resonance imaging [MRI] that can be used in humans to assess the effects of a given drug on the nociceptive system. If successful, these biomarkers would be used in future studies for the early stages of the pharmacological development of novel treatments for pain, and back-translated to animal models.
Publications
2021
IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).
Trials
Mouraux A, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Di Stefano G, Finnerup NB, Garcia-Larrea L, Goetz M, Kostenko A, Pelz B, Pogatzki-Zahn E, Schubart K, Stouffs A, Truini A, Tracey I, Troconiz IF, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Treede RD.
in press.
2021
Human surrogate models of central sensitization: a critical review and practical guide
European Journal of Pain
Quesada C, Kostenko A, Ho I, Leone C, Nochi Z, Stouffs A, Wittayer M, Caspani O, Finnerup NB, Mouraux A, Pickering G, Tracey I, Truini A, Treede RD, Garcia-Larrea L.
in press.
2020
Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study
Royal Society Open Science
van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM
in press.
2019
Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation
Journal of Neurophysiology
van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.
in press.
2019
IMI-PAINCARE, BIOPAIN : validation chez l'homme de nouveaux biomarqueurs fonctionnels pour le développement pharmacologique de traitements de la douleur
Douleur et Analgésie
Stouffs A, Lebrun L, Mouraux A.
in press.
2018
Philips Intellivue NMT module: variability of initial measurements
Journal of Clinical Monitoring and Computing
Stouffs A, Ibsen A, Jamart J, Dubois V, Dubois PE.
in press.
2016
Intraoperatively diagnosed tracheal tear during a parathyroidectomy with previously undiagnosed tracheomalacia: a case report
Acta Anaesthesiologica Belgica
Stouffs A, Scholtes JL.
in press.