André Mouraux - Principal investigator (IONS/COSY)
Group :

Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.
Publications
2021
Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin
J Pain
Courtin AS, Mouraux A
in press.
2021
The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons
Neurophysiol Clin
Di Pietro G, Di Stefano G, Leone C, Di Lionardo A, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Valeriani M, Truini A.
in press.
2021
Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
Scientific Reports
Di Lionardo A, Di Stefano G, Leone C, Di Pietro G, Sgro E, Malara E, Cosentino C, Mollica C, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Treede RD, Phillips KG, Valeriani M, Truini A.
in press.
2021
Vagus Nerve Stimulation elicits sleep EEG desynchronization and network changes in responder patients in epilepsy
Neurotherapeutics
Vespa S, Heyse J, Stumpp L, Liberati G, Ferrao Santos S, Rooijakkers H, Nonclercq A, Mouraux A, van Mierlo P, El Tahry R.
in press.
2021
How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex.
Clin Neurophysiol
Leone C, Di Lionardo A, Di Pietro G, Di Stefano G, Falco P, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Truini A.
in press.
2021
High-frequency electrical stimulation of cutaneous nociceptors differentially affects pain perception elicited by homotopic and heterotopic electrical stimuli
J Neurophysiol
van den Broeke EN, Urdi M, Mouraux A, Biurrun Manresa J, Torta DM
in press.
2021
IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).
Trials
Mouraux A, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Di Stefano G, Finnerup NB, Garcia-Larrea L, Goetz M, Kostenko A, Pelz B, Pogatzki-Zahn E, Schubart K, Stouffs A, Truini A, Tracey I, Troconiz IF, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Treede RD.
in press.
2021
Zero gravity induced by parabolic flight enhances automatic capture and weakens voluntary maintenance of visuospatial attention.
NPJ Microgravity
Salatino A, Iacono C, Gammeri R, Chiadò ST, Lambert J, Sulcova D, Mouraux A, George MS, Roberts DR, Berti A, Ricci R.
in press.
2021
Transcutaneous auricular VNS applied to experimental pain: A paired behavioral and EEG study using thermonociceptive CO2 laser.
PLoS One
Dumoulin M, Liberati G, Mouraux A, Santos SF, El Tahry R.
in press.
2021
Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder.
J Gambl Stud
Ninghetto M, Belli F, Nobili M, Mouraux A, Ricci R.
in press.
2021
Human surrogate models of central sensitization: a critical review and practical guide
European Journal of Pain
Quesada C, Kostenko A, Ho I, Leone C, Nochi Z, Stouffs A, Wittayer M, Caspani O, Finnerup NB, Mouraux A, Pickering G, Tracey I, Truini A, Treede RD, Garcia-Larrea L.
in press.
2021
Challenges and opportunities in translational pain research - an opinion paper of the working group on translational pain research of the European Pain Federation (EFIC)
European Journal of Pain
Mouraux A, Bannister K, Becker S, Finn DP, Pickering G, Pogatzki-Zahn E, Graven-Nielsen T.
in press.
2020
Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study
Royal Society Open Science
van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM
in press.
2020
Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
Nature: Scientific Reports
Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
in press.
2020
New insights into cutaneous laser stimulation – dependency on skin and laser type
Neuroscience
Frahm KS, Gervasio S, Arguissain F, Mouraux A.
in press.