André Mouraux - Principal investigator (IONS/COSY)
Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.
Spatial summation of cold and warm detection: evidence for increased precision when brisk stimuli are delivered over larger area
Courtin AS, Delvaux A, Dufour A, Mouraux A
Confidence of probabilistic predictions modulates the cortical response to pain
Mulders D, Seymour B, Mouraux A, Mancini F
High-speed heating of the skin using a contact thermode elicits comparable brain responses to those elicited by a CO2-laser device
Lejeune N, Petrossova E, Frahm KS, Mouraux A.
Characterization of vagus nerve stimulation-induced pupillary responses in epileptic patients
Vespa S, Stumpp L, Liberati G, Delbeke J, Nonclercq A, Mouraux A, El Tahry R
No evidence for an effect of selective spatial attention on the development of secondary hyperalgesia: a replication study
Front Hum Neurosci
Della Porta D, Vila ML, Kuzminova A, Filbrich L, Mouraux A, Legrain V.
Chronic temporomandibular disorders are associated with higher susceptibility to developing central sensitization: a case-control study
Cayrol T, van den Broeke EN, Gerard E, Meeus M, Mouraux A, Roussel N, Pitance L.
Olfactory dysfunction predicts frailty and poor postoperative outcome in older patients scheduled for elective non-cardiac surgery
J Nutr Health Aging
Van Regemorter V, Dollase J, Coulie R, Stouffs AD, de Saint-Hubert M, Mouraux A, Huart C.
IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity
Leone C, Di Stefano G, Di Pietro G, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Finnerup NB, Garcia-Larrea L, Li T, Goetz M, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Tracey I, Troconiz IF, Van Niel H, Hernandez JMV, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Truini A, Treede RD.
Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development
Int J Mol Sci
van Niel J, Bloms-Funke P, Caspani O, Cendros JM, Garcia-Larrea L, Truini A, Tracey I, Chapman SC, Marco-Ariño N, Troconiz IF, Phillips K, Finnerup NB, Mouraux A* and Treede RD
Multichannel transcranial direct current stimulation over the left dorsolateral prefrontal cortex may modulate the induction of secondary hyperalgesia, a double-blinded cross-over study in healthy volunteers.
Steyaert A, Lenoir C, Lavand'homme P, van den Broeke EN, Mouraux A.
Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: A systematic review of observational studies with meta-analysis
J Oral Rehabil
Cayrol T, Meeus M, Aron V, Gatto C, Mouraux A, Roussel NA, Sallaz L, van den Broeke EN, Pitance L.
IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).
Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.
Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin
Courtin AS, Mouraux A