Emanuel van den Broeke - postdoc (FRC)

Group : 

André Mouraux

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The main objective of my research is to study pain - or nociception- induced central nervous system plasticity. Currently, my studies are focused on characterizing changes in nociceptive pathways that lead or contribute to hyperalgesia, and I am, thereby, particularly interested in the phenomenon of "central sensitization"; the increase responsiveness of nociceptive neurons in the central nervous system that generates widespread hyperalgesia ("secondary hyperalgesia").

Publications

2022

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Chronic temporomandibular disorders are associated with higher susceptibility to developing central sensitization: a case-control study

Pain

Cayrol T, van den Broeke EN, Gerard E, Meeus M, Mouraux A, Roussel N, Pitance L.

in press.

2022

Multichannel transcranial direct current stimulation over the left dorsolateral prefrontal cortex may modulate the induction of secondary hyperalgesia, a double-blinded cross-over study in healthy volunteers.

PLoS One

Steyaert A, Lenoir C, Lavand'homme P, van den Broeke EN, Mouraux A.

in press.

2022

Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: A systematic review of observational studies with meta-analysis

J Oral Rehabil

Cayrol T, Meeus M, Aron V, Gatto C, Mouraux A, Roussel NA, Sallaz L, van den Broeke EN, Pitance L.

in press.

2021

High-frequency electrical stimulation of cutaneous nociceptors differentially affects pain perception elicited by homotopic and heterotopic electrical stimuli

J Neurophysiol

van den Broeke EN, Urdi M, Mouraux A, Biurrun Manresa J, Torta DM

in press.

2020

Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study

Royal Society Open Science

van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM

in press.

2020

Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

in press.

2020

Central sensitization of nociceptive pathways demonstrated by robot-controlled pinprick-evoked brain potentials

Clinical Neurophysiology

van den Broeke EN, de Hemptinne P, Mercken M, Torta DM, Lambert J, Mouraux A.

in press.

2020

Within- and between-session reliability of secondary hyperalgesia induced by electrical high-frequency stimulation

European Journal of Pain

Cayrol T, Lebleu J, Mouraux A, Roussel N, Pitance L, van den Broeke E.

in press.

2020

A highly cognitive demanding working memory task may prevent the development of nociceptive hypersensitivity

Pain

Torta DME, De Laurentis M, Eichin KN, Von Leupoldt A, van den Broeke EN, Vlaeyen J.

in press.

2020

Burst-like conditioning electrical stimulation is more efficacious than continuous stimulation for inducing secondary hyperalgesia in humans

Journal of Neurophysiology

Gousset S, Mouraux A, van den Broeke EN.

in press.

2020

The focus of spatial attention during the induction of central sensitization can modulate the subsequent development of secondary hyperalgesia

Cortex

Filbrich L, van den Broeke E, Legrain V, Mouraux .

in press.

2019

Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation

Journal of Neurophysiology

van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.

in press.

2019

Central sensitization in humans: Popular phrase or useful concept?

Journal of Psychosomatic Research

van den Broeke EN, Van den Bergh O.

in press.

2019

Central sensitization increases the pupil dilation elicited by mechanical pinprick stimulation

Journal of Neurophysiology

van den Broeke EN, Hartgerink DM, Butler J, Lambert J, Mouraux A.

in press.

2018

No evidence of widespread mechanical pressure hyperalgesia after experimentally-induced central sensitization via skin nociceptors

Pain Reports

Cayrol T, Pitance L, Roussel N, Mouraux A, van den Broeke EN.

in press.