Emmanuel Hermans - Principal investigator (IONS/CEMO)

Group : 

The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.

Publications

2019

Neurokinin-1 receptor-based bivalent drugs in pain management: The journey to nowhere?

Pharmacology & Therapeutics

Kleczkowska P, Nowicka K, Bujalska-Zadrozny M, Hermans E.

in press.

2019

Fibroadhesive scarring of grafted collagen scaffolds interferes with implant-host neural tissue integration and bridging in experimental spinal cord injury

Regenerative Biomaterials

Altinova H, Hammes S, Palm M, Gerardo-Nava J, Achenbach P, Deumens R, Hermans E, Führmann T, Boecker A, van Neerven SGA, Bozkurt A, Weis J, Brook GA.

in press.

2018

Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention

Brain, Behavior, and Immunity

Guillemot-Legris O, Buisseret B, Mutemberezi V, Hermans E, Deumens R, Alhouayek M, Muccioli GG.

in press.

2018

Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake

Glia

Vergouts M, Doyen PJ, Peeters M, Opsomer R, Hermans E.

in press.

2017

Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain

Journal of Neuroinflammation

Doyen PJ, Vergouts M, Pochet A, Desmet N, van Neerven S, Brook G, Hermans E.

in press.

2017

Immunohistochemical comparison of astrocytic mGluR5 upregulation in infraorbital nerve- versus sciatic nerve-ligated rat.

Neuroscience Letters

Michot B, Deumens R, Hermans E.

in press.

2017

PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes

Journal of Neurochemistry

Vergouts M, Doyen PJ, Peeters M, Opsomer R, Michiels T, Hermans E.

in press.

2017

Bilateral tactile hypersensitivity and neuroimmune responses after spared nerve injury in mice lacking vasoactive intestinal peptide

Experimental Neurology

Gallo A, Leerink M, Michot B, Ahmed E, Forget P, Mouraux A, Hermans E.

in press.

2016

A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity

Experimental Neurology

Taccola G, Doyen PJ, Damblon J, Dingu N, Ballarin B, Steyaert A, Rieux AD, Forget P, Hermans E, Bosier B, Deumens R.

in press.

2015

Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury

Nature : Scientific Reports.

Hoeber J, Trolle C, Konig N, Du Z, Gallo A, Hermans E, Aldskogius H, Shortland P, Zhang SC, Deumens R, Kozlova EN.

in press.

2015

Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling

British Journal of Pharmacology

Bosier B, Doyen PJ, Brolet A, Muccioli GG, Ahmed E, Desmet N, Hermans E, Deumens R.

in press.

2015

Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush

Neuroscience Research

Gallo A, Dimiziani A, Damblon J, Michot B, Des Rieux A, De Kock M, Hermans E, Deumens R.

in press.

2015

The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis

Experimental Neurology

Goursaud S, Schäfer S, Dumont AO, Vergouts M, Gallo A, Desmet N, Deumens R, Hermans E.

in press.

2014

Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury

Journal of Neuroinflammation

Schäfer S, Berger JV, Deumens R, Goursaud S, Hanisch UK, Hermans E.

in press.

2013

Schwann cell migration and neurite outgrowth are influenced by media conditioned by epineurial fibroblasts

Neuroscience

van Neerven SG, Pannaye P, Bozkurt A, Van Nieuwenhoven F, Joosten E, Hermans E, Taccola G, Deumens R.

in press.

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN