Role of the insula in nociception

A widely accepted notion is that one particular region of the “pain matrix”, the insula, plays a specific role in the perception of pain, and the activity recorded from this region is often considered as an objective signature of pain perception and its modulation.

Researchers involved

Publications

2020

Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

10: 22319

2018

Tonic thermonociceptive stimulation selectively modulates ongoing neural oscillations in the human posterior insula: evidence from intracerebral EEG

Neuroimage

Liberati G, Algoet M, Ferrao Santos S, Ribeiro-Vaz JG, Raftopoulos C, Mouraux A.

188:70-83

2018

Deep continuous theta burst stimulation of the operculo-insular cortex selectively affects Adelta-fiber heat pain

Journal of Physiology

Lenoir C*, Algoet M*, Mouraux A.

596(19):4767-4787

2018

Habituation of phase-locked local field potentials and gamma-band oscillations recorded from the human insula

Nature: Scientific Reports

Liberati G, Algoet M, Klöcker A, Ferrao Santos S, Ribeiro-Vaz JG, Raftopoulos C, Mouraux A.

8(1): 8265

2018

Report of one confirmed generalized seizure and one suspected partial seizure induced by deep continuous theta burst stimulation of the right operculo-insular cortex

Brain Stimulationation

Lenoir C*, Algoet M*, Vanderclausen C, Peeters A, Ferrao Santos S, Mouraux A.

11(5):1187-1188

2017

Gamma-band oscillations preferential for nociception can be recorded in the human insula

Cerebral Cortex

Liberati G, Klöcker A, Algoet M, Mulders D, Safronova MM, Ferrao Santos S, Vaz JG, Raftopoulos C, Mouraux A.

28(10):3650-3664.

2016

Nociceptive local field potentials recorded from the human insula are not specific for nociception

PLoS Biology

Liberati G, Klocker A, Safronova MM, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

14(1):e1002345

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN