Role of the insula in nociception
A widely accepted notion is that one particular region of the “pain matrix”, the insula, plays a specific role in the perception of pain, and the activity recorded from this region is often considered as an objective signature of pain perception and its modulation.

Researchers involved
Publications
2020
Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
Nature: Scientific Reports
Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
10: 22319
2018
Tonic thermonociceptive stimulation selectively modulates ongoing neural oscillations in the human posterior insula: evidence from intracerebral EEG
Neuroimage
Liberati G, Algoet M, Ferrao Santos S, Ribeiro-Vaz JG, Raftopoulos C, Mouraux A.
188:70-83
2018
Deep continuous theta burst stimulation of the operculo-insular cortex selectively affects Adelta-fiber heat pain
Journal of Physiology
Lenoir C*, Algoet M*, Mouraux A.
596(19):4767-4787
2018
Habituation of phase-locked local field potentials and gamma-band oscillations recorded from the human insula
Nature: Scientific Reports
Liberati G, Algoet M, Klöcker A, Ferrao Santos S, Ribeiro-Vaz JG, Raftopoulos C, Mouraux A.
8(1): 8265
2018
Report of one confirmed generalized seizure and one suspected partial seizure induced by deep continuous theta burst stimulation of the right operculo-insular cortex
Brain Stimulationation
Lenoir C*, Algoet M*, Vanderclausen C, Peeters A, Ferrao Santos S, Mouraux A.
11(5):1187-1188
2017
Gamma-band oscillations preferential for nociception can be recorded in the human insula
Cerebral Cortex
Liberati G, Klöcker A, Algoet M, Mulders D, Safronova MM, Ferrao Santos S, Vaz JG, Raftopoulos C, Mouraux A.
28(10):3650-3664.
2016
Nociceptive local field potentials recorded from the human insula are not specific for nociception
PLoS Biology
Liberati G, Klocker A, Safronova MM, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
14(1):e1002345