Laser-evoked brain potentials (LEPs)
In 1975, Mor and Carmon introduced infrared laser stimulators as tools to explore nociception in humans. Allowing brief, synchronous, and selective activation of cutaneous Adelta- and C-fibre nociceptors, laser heat stimulators are now used extensively to study nociception in humans.

Researchers involved
Publications
2020
Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
Nature: Scientific Reports
Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
10: 22319
2020
Rating the Intensity of a Laser Stimulus, but Not Attending to Changes in Its Location or Intensity Modulates the Laser-Evoked Cortical Activity
Frontiers in Human Neuroscience
Torta DME, Ninghetto M, Ricci R, Legrain V.
14:120
2020
Does motor cortex engagement during movement preparation differentially inhibit nociceptive processing in patients with chronic whiplash associated disorders, chronic fatigue syndrome and healthy controls? An experimental study
Journal of Clinical Medicine
Goudman L, Mouraux A, Daenen L, Nijs J, Cras P, Roussel N, Moens M, Lenoir D, Coppieters I, Huysmans E, De Kooning M.
9(5): E1520
2020
Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls: a case-control study
Pain Medicine
Goudman L, Daenen L, Mouraux A, Nijs J, Cras P, Roussel N, Moens M, Coppieters I, Huysmans E, De Kooning M.
21(10):2553-2563.
2020
Early gamma-oscillations as correlate of localized nociceptive processing in primary sensorimotor cortex
Journal of Neurophysiology
Heid C, Mouraux A, Treede RD, Schuh-Hofer S, Rupp A, Baumgärtner U.
123(5):1711-1726
2020
Rating the intensity of a laser stimulus, but not attending to changes in its location or intensity modulates the laser-evoked cortical activity
Frontiers in Human Neuroscience
Torta DME, Ninghetto M, Ricci R, Legrain V.
0.666666667
2020
Fibromyalgia syndrome - A laser-evoked potentials study unsupportive of small nerve fibre involvement
European Journal of Pain
Van Assche DCF, Plaghki L, Masquelier E, Hatem SM.
24(2):448-456
2018
Characterising the short-term habituation of event-related evoked potentials
eNeuro
Mancini F, Pepe A, Di Stefano G, Mouraux A, Iannetti GD.
5(5): ENEURO.0014-18.2018
2018
Quickly-responding C-fiber nociceptors contribute to heat hypersensitivity in the area of secondary hyperalgesia
Journal of Physiology
Lenoir C, Plaghki L, Mouraux A, van den Broeke EN.
in press
2018
Habituation of phase-locked local field potentials and gamma-band oscillations recorded from the human insula
Nature: Scientific Reports
Liberati G, Algoet M, Klöcker A, Ferrao Santos S, Ribeiro-Vaz JG, Raftopoulos C, Mouraux A.
8(1): 8265
2015
Electrophysiological techniques to study the supraspinal responses to nociceptive input in humans
Pain persistence after surgery and altered central processing: science and clinical practice
Mouraux A.
Wilder-Smith OHG, Arendt-Nielsen L, Yarnitski D and Vissers K (Eds). IASP Press
2015
Looking at the hand modulates the brain responses to nociceptive and non-nociceptive somatosensory stimuli but does not necessarily modulate their perception
Psychophysiology
Torta DM, Legrain V, Mouraux A.
52(8):1010-8