Neuropathic pain

Chronic pain is major healthcare problem worldwide, and pain relief often constitutes a problematic challenge to the physician. At present, laser-evoked potentials are considered to be the best available diagnostic tool to assess the function of the nociceptive system and to diagnose the neuropathic nature of pain. Currently, we are conducting a number of studies in humans aiming at better understanding the pathophysiological mechanisms leading to central and peripheral neuropathic pain. For example, the laboratory is developing new methods for the functional and structural characterization of small-fibre peripheral neuropathies (quantitative sensory testing, laser-evoked potentials, immunohistological assessment of skin biopsies), and to study the mechanisms involved in central pain related to syringomyelia.

Researchers involved

Publications

Journal of Neuroinflammation

Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain

2017

Doyen PJ, Vergouts M, Pochet A, Desmet N, van Neerven S, Brook G, Hermans E.

14(1):209

Acta Anaesthesiologica Belgica

Clinical evidence for dorsal root ganglion stimulation in the treatment of chronic neuropathic pain. A review.

2015

Forget P, Boyer T, Steyaert A, Masquelier E, Deumens R, Le Polain de Waroux B.

66(2):37-41

Nature : Scientific Reports.

Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury

2015

Hoeber J, Trolle C, Konig N, Du Z, Gallo A, Hermans E, Aldskogius H, Shortland P, Zhang SC, Deumens R, Kozlova EN.

5:10666

British Journal of Pharmacology

Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling

2015

Bosier B, Doyen PJ, Brolet A, Muccioli GG, Ahmed E, Desmet N, Hermans E, Deumens R.

72(22):5333-46

Neuroscience Research

Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush

2015

Gallo A, Dimiziani A, Damblon J, Michot B, Des Rieux A, De Kock M, Hermans E, Deumens R.

95:78-82

Douleur et Analgésie

PrÈdiction de la douleur postopÈratoire sÈvËre et de la persistance de la douleur postchirurgicale par des tests psychophysiques

2014

Plaghki L, Mouraux A.

27(3): 154-161

Journal of Neuroinflammation

Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury

2014

Schäfer S, Berger JV, Deumens R, Goursaud S, Hanisch UK, Hermans E.

0.567361111

Neuroscience Letters

Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity

2013

Leinders M, Knaepen L, De Kock M, Sommer C, Hermans E, Deumens R.

554:146-50

Journal of Neurology

Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potential

2011

Ragé M, Van Acker N, Knaapen MW, Timmers M, Streffer J, Hermans Mp, Sindic C, Meert T, Plaghki L.

258(10):1852-64

Journal of Neuroinflammation

Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1

2011

Berger JV, Deumens R, Goursaud S, Schäfer S, Lavandhomme P, Joosten EA, Hermans E.

08:33

European Journal of Pain

Multimodal therapeutic assessment of peripheral nerve stimulation in neuropathic pain: Five case reports with a 20-year follow-up

2011

Kupers R, Laere KV, Calenbergh FV, Gybels J, Dupont P, Baeck A, Plaghki L.

15(2): 161.e1-9

Brain

Clinical, functional and structural determinants of central pain in syringomyelia

2010

Hatem SM, Attal N, Ducreux D, Gautron M, Parker F, Plaghki L, Bouhassira D.

133(11):3409-22

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN