Neuropathic pain

Chronic pain is major healthcare problem worldwide, and pain relief often constitutes a problematic challenge to the physician. At present, laser-evoked potentials are considered to be the best available diagnostic tool to assess the function of the nociceptive system and to diagnose the neuropathic nature of pain. Currently, we are conducting a number of studies in humans aiming at better understanding the pathophysiological mechanisms leading to central and peripheral neuropathic pain. For example, the laboratory is developing new methods for the functional and structural characterization of small-fibre peripheral neuropathies (quantitative sensory testing, laser-evoked potentials, immunohistological assessment of skin biopsies), and to study the mechanisms involved in central pain related to syringomyelia.

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Researchers involved

Publications

2017

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Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain

Journal of Neuroinflammation

Doyen PJ, Vergouts M, Pochet A, Desmet N, van Neerven S, Brook G, Hermans E.

14(1):209

2015

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Clinical evidence for dorsal root ganglion stimulation in the treatment of chronic neuropathic pain. A review.

Acta Anaesthesiologica Belgica

Forget P, Boyer T, Steyaert A, Masquelier E, Deumens R, Le Polain de Waroux B.

66(2):37-41

2015

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Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury

Nature : Scientific Reports.

Hoeber J, Trolle C, Konig N, Du Z, Gallo A, Hermans E, Aldskogius H, Shortland P, Zhang SC, Deumens R, Kozlova EN.

5:10666

2015

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Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling

British Journal of Pharmacology

Bosier B, Doyen PJ, Brolet A, Muccioli GG, Ahmed E, Desmet N, Hermans E, Deumens R.

72(22):5333-46

2015

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Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush

Neuroscience Research

Gallo A, Dimiziani A, Damblon J, Michot B, Des Rieux A, De Kock M, Hermans E, Deumens R.

95:78-82

2014

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PrÈdiction de la douleur postopÈratoire sÈvËre et de la persistance de la douleur postchirurgicale par des tests psychophysiques

Douleur et Analgésie

Plaghki L, Mouraux A.

27(3): 154-161

2014

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Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury

Journal of Neuroinflammation

Schäfer S, Berger JV, Deumens R, Goursaud S, Hanisch UK, Hermans E.

0.567361111

2013

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Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity

Neuroscience Letters

Leinders M, Knaepen L, De Kock M, Sommer C, Hermans E, Deumens R.

554:146-50

2011

Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potential

Journal of Neurology

Ragé M, Van Acker N, Knaapen MW, Timmers M, Streffer J, Hermans Mp, Sindic C, Meert T, Plaghki L.

258(10):1852-64

2011

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Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1

Journal of Neuroinflammation

Berger JV, Deumens R, Goursaud S, Schäfer S, Lavandhomme P, Joosten EA, Hermans E.

08:33

2011

Multimodal therapeutic assessment of peripheral nerve stimulation in neuropathic pain: Five case reports with a 20-year follow-up

European Journal of Pain

Kupers R, Laere KV, Calenbergh FV, Gybels J, Dupont P, Baeck A, Plaghki L.

15(2): 161.e1-9

2010

Clinical, functional and structural determinants of central pain in syringomyelia

Brain

Hatem SM, Attal N, Ducreux D, Gautron M, Parker F, Plaghki L, Bouhassira D.

133(11):3409-22