Olfactory function and dysfunction in humans

Compared to other sensory modalities, the physiology and pathophysiology of olfaction remains poorly explored in humans. Yet, olfactory disorders are common in the general population, affecting up to 20% of the population. Over the recent years, the recording of ERPs triggered by the transient presentation of odorants has been receiving strong and increasing interest. The approach is not only of interest for basic researchers aiming to characterize the cortical representation of odors in humans. Indeed, it is also of great interest for clinicians currently needing objective and robust tools to diagnose disorders of olfaction. In addition, the recording of chemosensory ERPs could contribute to the early diagnosis of neurodegenerative disorders in which olfactory dysfunction is thought to constitute an early and specific sign, in particular, Alzheimer’s disease. Unfortunately, olfactory chemosensory ERPs exhibit a very low signal-to-noise ratio. Hence, although the technique is recognized as having great potential, its current usefulness remains very limited, particularly in the context of clinical diagnosis.

In a first project, we hypothesize that the low signal-to-noise ratio of chemosensory ERPs could at least in part be due to an important amount of temporal jitter affecting the brain responses to chemosensory stimulation, itself due to the number of steps required for transduction of the chemosensory stimulus into a neural impulse. For this reason, we develop an approach to reveal olfactory EEG responses that are not strictly phase-locked to the onset of the stimulus, using a method based on the continuous wavelet transform. We found that this approach significantly enhances the signal-to-noise ratio of the elicited responses, and discloses an important fraction of the cortical activity to chemosensory stimulation that is lost by conventional time-domain averaging. By providing a more complete view of how odors are represented in the human brain, we believe that our approach could constitute the basis for a robust clinical tool to assess olfaction in humans.

Researchers involved

Publications

2020

Adaptation of the Sniffin Sticks Test in South-Kivu

European Annals of Oto-rhino-laryngology, Head and Neck diseases

Balungwe P, Huart C, Matanda R, Bisimwa G, Mouraux A, Rombaux P.

S1879-7296(20)30032-6

2020

Mechanisms linking olfactory impairment and risk of mortality

Frontiers in Neuroscience

Van Regemorter V , Hummel T, Rosenzweig F, Mouraux A, Rombaux P, Huart C.

0.680555556

2019

Development of a new psychophysical method to assess intranasal trigeminal chemosensory function

Rhinology

Huart C, Hummel T, Kaehling C, Konstantinidis I, Hox V, Mouraux A, Rombaux P.

57(5): 375-384

2019

Neural plasticity in developing and adult olfactory pathways - focus on the human olfactory bulb

Journal of Bioenergetics and Biomembranes

Huart C, Rombaux P, Hummel T.

51(1):77-87

2018

Parkinson disease in eldery patients: lessons from odour detection thresholds on olfacto-trigeminal interaction

Rhinology

Foguem C, Lemdani M, Huart C.

56(2):127-132

2016

Brain lesion-pattern analysis in patients with olfactory dysfunctions following head trauma

Neuroimage Clinical

Lötsch J, Ultsch A, Eckhardt M, Huart C, Rombaux P, Hummel T.

11:99-105

2016

Post-injury smell disorders

B-ENT

Rombaux P, Huart C, Balungwe P, de Toeuf C, Collet S, Duprez T.

Suppl 26(2):39-46

2016

Olfaction in Chronic Rhinosinusitis

Current Allergy and Asthma Reports

Rombaux P, Huart C, Levie P, Cingi C, Hummel T.

16(5):41

2015

Unirhinal olfactory testing for the diagnostic workup of mild cognitive impairment

Journal of Alzheimer's Disease

Huart C, Rombaux P, Gérard T, Hanseeuw B, Lhommel R, Quenon L, Ivanoiu A, Mouraux A.

47(1): 253-270

2015

Volume of olfactory bulb and depth of olfactory sulcus in 378 consecutive patients with olfactory loss

Journal of Neurology

Hummel T, Urbig A, Huart C, Duprez T, Rombaux P.

262(4):1046-51

2014

Olfactory event-related potentials in infants

The Journal of Pediatrics

Schriever VA, Gois-Eanes M, Schuster B, Huart C, Hummel T.

165(2): 372-375

2013

Plasticity of the human olfactory system : the olfactory bulb

Molecules

Huart C, Rombaux P, Hummel T.

18(9): 11586-600

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN