NOCIONS all publications
NOCIONS all publications
Questioning the functional significance of the pain matrix
Neuroimaging and neurophysiological studies have shown that transient nociceptive stimuli elicit responses in an extensive cortical network including somatosensory, insular and cingulate areas, as well as frontal and parietal areas. A long-standing view in the field of pain research has been that this network, often referred to as the “pain matrix”, represents the neural activity through which pain emerges as a percept. Recently, we have performed a number of studies challenging this interpretation. First, we conducted a number of experiments showing that pain intensity can be entirely dissociated from the magnitude of the responses in the so-called “pain matrix”, and that the magnitude of the elicited brain responses are strongly influenced by the context within which the stimulus appears, in particular, stimulus novelty. Second, using EEG and fMRI, we showed that non-nociceptive stimuli as well as stimuli not perceived as painful can elicit cortical responses having a spatial distribution that is indistinguishable from that of the “pain matrix”. For these different reasons, we proposed an alternative view of the functional significance of the “pain matrix”, in which it would reflect a system involved in detecting, orientation attention towards, and reacting to the occurrence of salient and/or behaviorally-relevant sensory events. Furthermore, we postulate that this cortical network might represent a basic mechanism through which significant events for the body’s integrity are detected, regardless of the sensory channel through which these events are conveyed.
Researchers involved
Publications
2019
Spatial Patterns of Brain Activity Preferentially Reflecting Transient Pain and Stimulus Intensity
Cerebral Cortex
Liang M, Su Q, Mouraux A, Iannetti GD.
29(5):2211-2227
2019
Brain regions preferentially responding to transient and iso-intense painful or tactile stimuli
Neuroimage
Su Q, Qin W, Yang QQ, Yu CS, Qian TY, Mouraux A, Iannetti GD, Liang M.
192:52-65
2018
The search for pain biomarkers in the human brain
Brain
Mouraux A, Iannetti GD.
141(12):3290-3307
2017
The human primary somatosensory cortex is differentially involved in vibrotaction and nociception
Journal of Neurophysiology
Lenoir C, Huang G, Vandermeeren Y, Hatem SM, Mouraux A.
118(1):317-330
2016
Nociceptive local field potentials recorded from the human insula are not specific for nociception
PLoS Biology
Liberati G, Klocker A, Safronova MM, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
14(1):e1002345
2015
The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs
Human Brain Mapping
Hu L, Zhang L, Chen R, Yu H, Li H, Mouraux A.
36(11):4346-60
2015
Evoked potentials in relation to pain perception
The brain adapting with pain: Contribution of neuroimaging technology to pain mechanisms
Mouraux A, Iannetti GD, Baumgartner U, Treede RD.
Apkarian AV (Ed). IASP Press.
2015
The pain matrix: myths and (unpleasant) truths
The brain adapting with pain: Contribution of neuroimaging technology to pain mechanisms
Iannetti GD, Mouraux A.
Apkarian AV (Ed). IASP Press.
2014
EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli
Journal of Cognitive Neuroscience
Colon E, Legrain V, Mouraux A.
26(10):2262-74
2013
Unmasking the obligatory components of nociceptive event-related brain potentials
Journal of Neurophysiology
Mouraux A, De Paepe AL, Marot E, Plaghki L, Iannetti GD, Legrain V.
110(10):2312-24
2013
Primary Sensory Cortices Contain Distinguishable Spatial Patterns of Activity for Each Sense
Nature Communications
Liang M, Mouraux A, Hu L, Iannetti GD.
1.540972222
2013
Beyond metaphor: Contrasting mechanisms of social and physical pain
TRENDS in Cognitive Sciences
Iannetti GD, Salomons TV, Moayedi M, Mouraux A, Davis KD.
17(8): 371-8