TMS and tDCS combined with EEG and fMRI to characterize the organization and interdependency of brain areas involved in nociception

In this project, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) is combined with EEG and functional MRI to characterize the organization and interdependencies between different brain areas involved in processing somatosensory and nociceptive inputs and in the perception of pain in humans. Two approaches are used. In the first approach, brain responses to nociceptive stimuli are sampled using EEG and fMRI, before and after modulating the excitability of a specific brain region using repetitive TMS or tDCS. In the second approach, brain responses elicited by a single pulse of TMS applied over a given brain region are sampled using online EEG or FMRI, such as to characterize changes in functional connectivity related to central sensitization.

Researchers involved

Publications

Neuroscience

Anodal transcutaneous spinal direct current stimulation (tsDCS) selectively inhibits the synaptic efficacy of nociceptive transmission at spinal cord level

2018

Lenoir C, Jankovski A, Mouraux A.

393:150-163

Journal of Physiology

Deep continuous theta burst stimulation of the operculo-insular cortex selectively affects Adelta-fiber heat pain

2018

Lenoir C*, Algoet M*, Mouraux A.

596(19):4767-4787

Neuroscience

Temporal profile and limb-specificity of phasic pain-evoked changes in motor excitability

2018

Algoet M, Duqué J, Iannetti GD, Mouraux A.

386: 240-255

Brain Stimulationation

Report of one confirmed generalized seizure and one suspected partial seizure induced by deep continuous theta burst stimulation of the right operculo-insular cortex

2018

Lenoir C*, Algoet M*, Vanderclausen C, Peeters A, Ferrao Santos S, Mouraux A.

11(5):1187-1188

Journal of Neurophysiology

The human primary somatosensory cortex is differentially involved in vibrotaction and nociception

2017

Lenoir C, Huang G, Vandermeeren Y, Hatem SM, Mouraux A.

118(1):317-330

PLoS ONE

MEP latencies predict the neuromodulatory effect of cTBS delivered to the ipsilateral and contralateral sensorimotor cortex

2015

Huang G, Mouraux A.

PLoS ONE

Theta burst stimulation applied over primary motor and somatosensory cortices produces analgesia unrelated to the changes in nociceptive event-related potentials

2013

Torta D, Legrain V, Algoet M, Olivier E, Duqué J, Mouraux A.

20; 8(8): e73263

EEG-fMRI

Combining EEG and fMRI in pain research

2008

Iannetti GD, Mouraux A.

L Lemieux, C Mulert, editors. New York: Springer-Verlag

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN