TMS and tDCS combined with EEG and fMRI to characterize the organization and interdependency of brain areas involved in nociception
In this project, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) is combined with EEG and functional MRI to characterize the organization and interdependencies between different brain areas involved in processing somatosensory and nociceptive inputs and in the perception of pain in humans. Two approaches are used. In the first approach, brain responses to nociceptive stimuli are sampled using EEG and fMRI, before and after modulating the excitability of a specific brain region using repetitive TMS or tDCS. In the second approach, brain responses elicited by a single pulse of TMS applied over a given brain region are sampled using online EEG or FMRI, such as to characterize changes in functional connectivity related to central sensitization.
Publications
Anodal transcutaneous spinal direct current stimulation (tsDCS) selectively inhibits the synaptic efficacy of nociceptive transmission at spinal cord level
Lenoir C, Jankovski A, Mouraux A.
Deep continuous theta burst stimulation of the operculo-insular cortex selectively affects Adelta-fiber heat pain
Lenoir C*, Algoet M*, Mouraux A.
Temporal profile and limb-specificity of phasic pain-evoked changes in motor excitability
Algoet M, Duqué J, Iannetti GD, Mouraux A.
Report of one confirmed generalized seizure and one suspected partial seizure induced by deep continuous theta burst stimulation of the right operculo-insular cortex
Lenoir C*, Algoet M*, Vanderclausen C, Peeters A, Ferrao Santos S, Mouraux A.
Journal of Neurophysiology
The human primary somatosensory cortex is differentially involved in vibrotaction and nociception
Lenoir C, Huang G, Vandermeeren Y, Hatem SM, Mouraux A.
MEP latencies predict the neuromodulatory effect of cTBS delivered to the ipsilateral and contralateral sensorimotor cortex
Theta burst stimulation applied over primary motor and somatosensory cortices produces analgesia unrelated to the changes in nociceptive event-related potentials
Torta D, Legrain V, Algoet M, Olivier E, Duqué J, Mouraux A.
Combining EEG and fMRI in pain research
L Lemieux, C Mulert, editors. New York: Springer-Verlag
