TMS and tDCS combined with EEG and fMRI to characterize the organization and interdependency of brain areas involved in nociception
In this project, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) is combined with EEG and functional MRI to characterize the organization and interdependencies between different brain areas involved in processing somatosensory and nociceptive inputs and in the perception of pain in humans. Two approaches are used. In the first approach, brain responses to nociceptive stimuli are sampled using EEG and fMRI, before and after modulating the excitability of a specific brain region using repetitive TMS or tDCS. In the second approach, brain responses elicited by a single pulse of TMS applied over a given brain region are sampled using online EEG or FMRI, such as to characterize changes in functional connectivity related to central sensitization.

Researchers involved
Publications
2022
Multichannel transcranial direct current stimulation over the left dorsolateral prefrontal cortex may modulate the induction of secondary hyperalgesia, a double-blinded cross-over study in healthy volunteers.
PLoS One
Steyaert A, Lenoir C, Lavand'homme P, van den Broeke EN, Mouraux A.
17(6):e0270047.
2018
Anodal transcutaneous spinal direct current stimulation (tsDCS) selectively inhibits the synaptic efficacy of nociceptive transmission at spinal cord level
Neuroscience
Lenoir C, Jankovski A, Mouraux A.
393:150-163
2018
Deep continuous theta burst stimulation of the operculo-insular cortex selectively affects Adelta-fiber heat pain
Journal of Physiology
Lenoir C*, Algoet M*, Mouraux A.
596(19):4767-4787
2018
Temporal profile and limb-specificity of phasic pain-evoked changes in motor excitability
Neuroscience
Algoet M, Duqué J, Iannetti GD, Mouraux A.
386: 240-255
2018
Report of one confirmed generalized seizure and one suspected partial seizure induced by deep continuous theta burst stimulation of the right operculo-insular cortex
Brain Stimulationation
Lenoir C*, Algoet M*, Vanderclausen C, Peeters A, Ferrao Santos S, Mouraux A.
11(5):1187-1188
2017
The human primary somatosensory cortex is differentially involved in vibrotaction and nociception
Journal of Neurophysiology
Lenoir C, Huang G, Vandermeeren Y, Hatem SM, Mouraux A.
118(1):317-330
2015
MEP latencies predict the neuromodulatory effect of cTBS delivered to the ipsilateral and contralateral sensorimotor cortex
PLoS ONE
Huang G, Mouraux A.
2013
Theta burst stimulation applied over primary motor and somatosensory cortices produces analgesia unrelated to the changes in nociceptive event-related potentials
PLoS ONE
Torta D, Legrain V, Algoet M, Olivier E, Duqué J, Mouraux A.
20; 8(8): e73263
2008
Combining EEG and fMRI in pain research
EEG-fMRI
Iannetti GD, Mouraux A.
L Lemieux, C Mulert, editors. New York: Springer-Verlag