De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A. EClin Neurophysiol (2018); in press.
Pain research at the Institute of Neuroscience (IONS)
Université catholique de Louvain (UCL)
The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.
Basic, translational and clinical pain research at the Institute of Neuroscience (IONS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute.
André Mouraux pain research EEG nociception letswave software analysis free matlab wavelets toolbox nocions
|Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.|
|The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.
|Letswave is a free toolbox to analyze electroencephalographic (EEG) and other neurophysiological signals, running in Matlab. As compared to existing signal processing toolboxes, emphasis is placed on intuitive and streamlined tools to process and visualize neurophysiological signals, with a shallow learning curve. The new version provides advanced scripting possibilities.|
Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans
Investigating the spatial characteristics of the crossmodal interaction between nociception and vision using gaze direction
Filbrich L, Halicka M. Alamia A. Legrain V. Consciousness and Cognition (2018); 57: 106-115. [PDF]
Filbrich L, Alamia A, Verfaille C, Barbier O, Libouton X, Fraselle V, Mouraux D, Berquin A, Legrain V. Sci Rep (2017); 7:9712. [PDF]
Nozaradan S, Keller PE, Rossion B, Mouraux A. Brain Topogr (2017); in press. [PDF]
Guillery E, Mouraux A, Thonnard JL, Legrain V. Front Behav Neurosci (2017); 11:220. [PDF]
Gueorguiev D, Vezzoli E, Mouraux A, Lemaire-Semail B, Thonnard JL. J R Soc Interface (2017); 14(137). pii: 20170641. [PDF]
Lange J, Massart C, Mouraux A, Standaert FX. In: COSADE 2017: Constructive side-channel analysis and secure design. (2017). S. Guilley (Ed.), pp. 171-189. [PDF]
Liberati G, Klöcker A, Algoet M, Mulders D, Safronova MM, Ferrao Santos S, Vaz JG, Raftopoulos C, Mouraux A. Cerebral Cortex (2017); in press. [PDF]
Shaping visual space perception through bodily sensations: Testing the impact of nociceptive stimuli on visual perception in peripersonal space with temporal order judgments
Filbrich L, Alamia A, Blandiaux S, Burns S, Legrain V. PLoS One (2017);12(8):e0182634. [PDF]
Vanderclausen C, Filbrich L, Alamia A, Legrain V. Neurosci Lett (2017); 654: 111-116. [PDF]
Phase-locked and non-phase-locked EEG responses to pinprick stimulation before and after experimentally-induced secondary hyperalgesia
van den Broeke EN, de Vries B, Lambert J, Torta DM, Mouraux A. Clin Neurophysiol (2017); 128(8):1445-1456. [PDF]
Lenoir C, Huang G, Vandermeeren Y, Hatem SM, Mouraux A. J Neurophysiol (2017); 118(1):317-330.
De Paepe AL, Crombez G, Legrain V. Neuropsychologia (2017); 101:121-131.
Legrain V. Brain (2017); 140(9):2254-2256. [PDF]
Orienting attention in visual space by nociceptive stimuli. Investigation with temporal order judgment tasks based on the adaptive PSI method.
Filbrich L, Alamia A, Burns S, Legrain V. Exp Brain Res (2017); 235(7):2069-2079. [PDF]
Nozaradan S, Mouraux A, Cousineau M. J Neurophysiol (2017); 118(1):243-253. [PDF]
Bilateral tactile hypersensitivity and neuroimmune responses after spared nerve injury in mice lacking vasoactive intestinal peptide
Gallo A, Leerink M, Michot B, Ahmed E, Forget P, Mouraux A, Hermans E. Exp Neurol (2017); 293:62-73. [PDF]
Attention to pain! A neurocognitive perspective on attentional modulation of pain in neuroimaging studies
Torta D, Legrain V, Mouraux A, Valentini E. Cortex (2017); 89:120-134. [PDF]
Intense pain influences the cortical processing of visual stimuli projected onto the sensitized skin
Torta DM, van den Broeke EN, Filbrich L, Jacob B, Lambert J, Mouraux A. Pain (2017); 158(4):691-697. [PDF]
Orban de Xivry J.J., Legrain V., Lefèvre P. J Neurophysiol (2016); 117(1):117-122. [PDF]
Nozaradan S, Mouraux A, Jonas J, Colnat-Coulbois S, Rossion B, Maillard L. Brain Struct Func (2017); 222(5):2389-2404. [PDF]
Feasibility of Topical Applications of Natural High-Concentration Capsaicinoid Solutions in Patients with Peripheral Neuropathic Pain: A Retrospective Analysis
Bauchy F, Mouraux A, Deumens R, Leerink M, Ulpiano Trillig A, le Polain de Waroux B, Steyaert A, Quetin-Leclercq J, Forget P. Pain Research and Management (2016): 9703036. [PDF]
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A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity
Taccola G, Doyen PJ, Damblon J, Dingu N, Ballarin B, Steyaert A, Rieux AD, Forget P, Hermans E, Bosier B, Deumens R. Exp Neurol (2016); 286:1-11. [PDF]
EEG frequency tagging using ultra-slow periodic heat stimulation of the skin reveals cortical activity specifically related to C fiber thermonociceptors
Colon E, Liberati G, Mouraux A. Neuroimage (2016); 146:266-274. [PDF]
Mechanical pinprick pain in patients with unilateral spatial neglect: The influence of space representation on the perception of nociceptive stimuli
Vizzari V, Barba S, Gindri P, Duca S, Giobbe D, Cerrato P, Geminiani G, Torta DM. Eur J Pain (2016); 21(4):738-749. [PDF]
Central sensitization of mechanical nociceptive pathways is associated with a long-lasting increase of pinprick-evoked brain potentials
van den Broeke E, Lambert J, Huang G, Mouraux A. Front Hum Neurosci (2016); 10:531. [PDF]
Nozaradan S, Schönwiesner M, Caron-Desrochers L, Lehmann A. Neuroimage (2016); 142:231-240. [PDF]
Absence of Evidence or Evidence of Absence? Commentary: Captured by the pain: Pain steady-state evoked potentials are not modulated by selective spatial attention
Colon E, Mouraux A. Front Hum Neurosci (2016); 0:252. [PDF]
van den Broeke E, Lenoir C, Mouraux A. J Physiol (2016); 594(22):6767-6776. [PDF]