Emmanuel Hermans - Principal investigator (IONS/CEMO)

The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.

Group members

Publications

Pharmacology & Therapeutics

Neurokinin-1 receptor-based bivalent drugs in pain management: The journey to nowhere?

2020

Kleczkowska P, Nowicka K, Bujalska-Zadrozny M, Hermans E.

196:44-58

Regenerative Biomaterials

Fibroadhesive scarring of grafted collagen scaffolds interferes with implant-host neural tissue integration and bridging in experimental spinal cord injury

2020

Altinova H, Hammes S, Palm M, Gerardo-Nava J, Achenbach P, Deumens R, Hermans E, Führmann T, Boecker A, van Neerven SGA, Bozkurt A, Weis J, Brook GA.

6(2):75-87

Brain, Behavior, and Immunity

Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention

2020

Guillemot-Legris O, Buisseret B, Mutemberezi V, Hermans E, Deumens R, Alhouayek M, Muccioli GG.

74:96-105

Glia

Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake

2020

Vergouts M, Doyen PJ, Peeters M, Opsomer R, Hermans E.

Journal of Neuroinflammation

Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain

2020

Doyen PJ, Vergouts M, Pochet A, Desmet N, van Neerven S, Brook G, Hermans E.

14(1):209

Neuroscience Letters

Immunohistochemical comparison of astrocytic mGluR5 upregulation in infraorbital nerve- versus sciatic nerve-ligated rat.

2020

Michot B, Deumens R, Hermans E.

653:113-119

Journal of Neurochemistry

PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes

2020

Vergouts M, Doyen PJ, Peeters M, Opsomer R, Michiels T, Hermans E.

141(3):387-399

Experimental Neurology

Bilateral tactile hypersensitivity and neuroimmune responses after spared nerve injury in mice lacking vasoactive intestinal peptide

2020

Gallo A, Leerink M, Michot B, Ahmed E, Forget P, Mouraux A, Hermans E.

293:62-73

Experimental Neurology

A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity

2020

Taccola G, Doyen PJ, Damblon J, Dingu N, Ballarin B, Steyaert A, Rieux AD, Forget P, Hermans E, Bosier B, Deumens R.

286:1-11

Nature : Scientific Reports.

Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury

2020

Hoeber J, Trolle C, Konig N, Du Z, Gallo A, Hermans E, Aldskogius H, Shortland P, Zhang SC, Deumens R, Kozlova EN.

5:10666

British Journal of Pharmacology

Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling

2020

Bosier B, Doyen PJ, Brolet A, Muccioli GG, Ahmed E, Desmet N, Hermans E, Deumens R.

72(22):5333-46

Neuroscience Research

Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush

2020

Gallo A, Dimiziani A, Damblon J, Michot B, Des Rieux A, De Kock M, Hermans E, Deumens R.

95:78-82

Experimental Neurology

The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis

2020

Goursaud S, Schäfer S, Dumont AO, Vergouts M, Gallo A, Desmet N, Deumens R, Hermans E.

263:91-101

Journal of Neuroinflammation

Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury

2020

Schäfer S, Berger JV, Deumens R, Goursaud S, Hanisch UK, Hermans E.

0.567361111

Neuroscience

Schwann cell migration and neurite outgrowth are influenced by media conditioned by epineurial fibroblasts

2020

van Neerven SG, Pannaye P, Bozkurt A, Van Nieuwenhoven F, Joosten E, Hermans E, Taccola G, Deumens R.

252:144-53

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN