NOCIONS all publications
NOCIONS all publications
Emmanuel Hermans - Principal investigator (IONS/CEMO)
The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
Group members
Publications
2022
AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport
Cells
Belo do Nascimento I, Verfaillie M, Ates G, Beckers P, Joris V, Desmet N, Massie A, Hermans E.
11(11):1800.
2021
Receptor density influences ligand-induced dopamine D2L receptor homodimerization
Eur J Pharmacol
Ferraiolo M, Atik H, Ponthot R, Belo do Nascimento I, Beckers P, Stove C, Hermans E.
911:174557.
2019
Neurokinin-1 receptor-based bivalent drugs in pain management: The journey to nowhere?
Pharmacology & Therapeutics
Kleczkowska P, Nowicka K, Bujalska-Zadrozny M, Hermans E.
196:44-58
2019
Fibroadhesive scarring of grafted collagen scaffolds interferes with implant-host neural tissue integration and bridging in experimental spinal cord injury
Regenerative Biomaterials
Altinova H, Hammes S, Palm M, Gerardo-Nava J, Achenbach P, Deumens R, Hermans E, Führmann T, Boecker A, van Neerven SGA, Bozkurt A, Weis J, Brook GA.
6(2):75-87
2018
Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention
Brain, Behavior, and Immunity
Guillemot-Legris O, Buisseret B, Mutemberezi V, Hermans E, Deumens R, Alhouayek M, Muccioli GG.
74:96-105
2018
Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake
Glia
Vergouts M, Doyen PJ, Peeters M, Opsomer R, Hermans E.
2017
Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain
Journal of Neuroinflammation
Doyen PJ, Vergouts M, Pochet A, Desmet N, van Neerven S, Brook G, Hermans E.
14(1):209
2017
Immunohistochemical comparison of astrocytic mGluR5 upregulation in infraorbital nerve- versus sciatic nerve-ligated rat.
Neuroscience Letters
Michot B, Deumens R, Hermans E.
653:113-119
2017
PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes
Journal of Neurochemistry
Vergouts M, Doyen PJ, Peeters M, Opsomer R, Michiels T, Hermans E.
141(3):387-399
2015
Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury
Nature : Scientific Reports.
Hoeber J, Trolle C, Konig N, Du Z, Gallo A, Hermans E, Aldskogius H, Shortland P, Zhang SC, Deumens R, Kozlova EN.
5:10666
2015
Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling
British Journal of Pharmacology
Bosier B, Doyen PJ, Brolet A, Muccioli GG, Ahmed E, Desmet N, Hermans E, Deumens R.
72(22):5333-46
2015
Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush
Neuroscience Research
Gallo A, Dimiziani A, Damblon J, Michot B, Des Rieux A, De Kock M, Hermans E, Deumens R.
95:78-82
2015
The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis
Experimental Neurology
Goursaud S, Schäfer S, Dumont AO, Vergouts M, Gallo A, Desmet N, Deumens R, Hermans E.
263:91-101