NOCIONS all publications
NOCIONS all publications
Louisien Lebrun (Hôpital Erasme) - former PhD student
Former PhD student at NOCIONS. My PhD was conducted in the framework of an Innovative Medicines Initiative (IMI PAIN-CARE; https://www.imi-paincare.eu) project, subtopic BioPain. The aim was to identify and validate a number of functional biomarkers based on non-invasive measures of neural activity (peripheral measures of nerve excitability, spinal and brainstem reflexes, measures of brain activity using electroencephalography [EEG] and functional magnetic resonance imaging [MRI] that can be used in humans to assess the effects of a given drug on the nociceptive system. These biomarkers could be used in future studies for the early stages of the pharmacological development of novel treatments for pain, and back-translated to animal models.
Publications
2025
Interindividual variations in peak alpha frequency do not predict the magnitude or extent of secondary hyperalgesia induced by high-frequency stimulation
J Neurophysiol
Lebrun L, Ricci G, Courtin A, van den Broeke EN, Lenoir C, Mouraux A
in press
Strength, extent and duration of secondary hyperalgesia induced by high-frequency electrical stimulation of the foot compared to the volar forearm of healthy human volunteers
PLoS One
Lebrun L, Lenoir C, Leone C, van den Broeke EN, Caspani O, Schilder A, Pelz B, Truini A, Treede RD, Mouraux A
20(2):e0318934.
2019
IMI-PAINCARE, BIOPAIN : validation chez l'homme de nouveaux biomarqueurs fonctionnels pour le développement pharmacologique de traitements de la douleur
Douleur et Analgésie
Stouffs A, Lebrun L, Mouraux A.
31(4): 230