Opsommer E, Masquelier E, Plaghki L. Neurophysiol Clin 1999;29(5):411-422. [PDF]
Pain research at the Institute of Neuroscience (IONS)
Université catholique de Louvain (UCL)
The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.
Basic, translational and clinical pain research at the Institute of Neuroscience (IONS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute.
André Mouraux pain research EEG nociception letswave software analysis free matlab wavelets toolbox nocions
|Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.|
|The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
The research group of Prof. Emmanuel Hermans (IONS/CEMO) has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.
|Letswave is a free toolbox to analyze electroencephalographic (EEG) and other neurophysiological signals, running in Matlab. As compared to existing signal processing toolboxes, emphasis is placed on intuitive and streamlined tools to process and visualize neurophysiological signals, with a shallow learning curve. The new version provides advanced scripting possibilities.|
Determination of nerve conduction velocity of C-fibres in humans from thermal thresholds to contact heat (thermode) and from evoked brain potentials to radiant heat (CO2 laser).
Masquelier E, Plaghki L. CME Tutorial 42 Pain digest, 9, 1999, p. 258-259.
Grisart JM, Plaghki LH. Eur J Pain 1999;3(4):325-333.
Neuromodulation of pain. A consensus statement prepared in Brussels 16-18 January 1998 by the following task force of the European Federation of IASP Chapters (EFIC).
Gybels J, Erdine S, Maeyaert J, Meyerson B, Winkelmuller W, Augustinsson L, Bonezzi C, Brasseur L, DeJongste M, Kupers R, Marchettini P, Muller-Schwefe G, Nitescu P, Plaghki L, Reig E, Spincemaille G, Thomson S, Tronnier V, Van Buyten JP. Eur J Pain 1998;2(3):203-209.
Plaghki L, Bragard D, Le Bars D, Willer JC, Godfraind JM. J Neurophysiol 1998;79(5):2557-2567. [PDF]
Objective measures of muscle stiffness in the ankle. Evaluation of the effect of intrathecal injection of baclofen in spastic patients.
Detrembleur C, Lejeune TM, Plaghki L. Neurochirurgie 1998;44(3):197-200.
Detrembleur C, Willems P, Plaghki L. Dev Med Child Neurol 1997;39(12):803-807.
Lejeune TM, Detrembleur CD, DeNayer JA, Plaghki LH. Arch Phys Med Rehabil 1996;77(8):827-829.
Noel-Jorand MC, Bragard D, Plaghki L. Eur J Neurosci 1996;8(10):2075-2079.
Direct isolation of ultra-late (C-fibre) evoked brain potentials by CO2 laser stimulation of tiny cutaneous surface areas in man.
Bragard D, Chen AC, Plaghki L. Neurosci Lett 1996;209(2):81-84. [PDF]
Heterotopic nociceptive conditioning stimuli and mental task modulate differently the perception and physiological correlates of short CO2 laser stimuli.
Plaghki L, Delisle D, Godfraind JM. Pain 1994;57(2):181-192. [PDF]
Nielens H, Plaghki L. Clin J Pain 1994;10(3):204-209.