NOCIONS all publications
NOCIONS all publications
Maxime Algoet - former PhD student
Group :
André Mouraux
The general objective of my PhD project was to develop novel noninvasive means to characterize activity-dependent changes in brain function related to central sensitization and chronic pain. At the core of my project was the development of a novel approach based on the recording of TMS-evoked BOLD responses sampled using concurrent TMS-fMRI. As a first step, this was used to characterize changes in cortical excitability and functional connectivity within different brain areas induced by a sustained experimental pain. Subsequently, this approach could be used to study changes in brain function related to chronic pain. In parallel, I was also interested in studying the changes in motor excitability induced by an experimental pain. I combined TMS of the primary motor cortex with, respectively, brief and sustained nociceptive stimulation to characterize the spinal and supraspinal pain-motor interactions triggered by noxious stimulation