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Laser-evoked brain potentials (LEPs)

In 1975, Mor and Carmon introduced infrared laser stimulators as tools to explore nociception in humans. Allowing brief, synchronous, and selective activation of cutaneous Adelta- and C-fibre nociceptors, laser heat stimulators are now used extensively to study nociception in humans.

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Researchers involved



Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

10: 22319


Rating the Intensity of a Laser Stimulus, but Not Attending to Changes in Its Location or Intensity Modulates the Laser-Evoked Cortical Activity

Frontiers in Human Neuroscience

Torta DME, Ninghetto M, Ricci R, Legrain V.



Does motor cortex engagement during movement preparation differentially inhibit nociceptive processing in patients with chronic whiplash associated disorders, chronic fatigue syndrome and healthy controls? An experimental study

Journal of Clinical Medicine

Goudman L, Mouraux A, Daenen L, Nijs J, Cras P, Roussel N, Moens M, Lenoir D, Coppieters I, Huysmans E, De Kooning M.

9(5): E1520


Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls: a case-control study

Pain Medicine

Goudman L, Daenen L, Mouraux A, Nijs J, Cras P, Roussel N, Moens M, Coppieters I, Huysmans E, De Kooning M.



Early gamma-oscillations as correlate of localized nociceptive processing in primary sensorimotor cortex

Journal of Neurophysiology

Heid C, Mouraux A, Treede RD, Schuh-Hofer S, Rupp A, Baumgärtner U.



Rating the intensity of a laser stimulus, but not attending to changes in its location or intensity modulates the laser-evoked cortical activity

Frontiers in Human Neuroscience

Torta DME, Ninghetto M, Ricci R, Legrain V.



Fibromyalgia syndrome - A laser-evoked potentials study unsupportive of small nerve fibre involvement

European Journal of Pain

Van Assche DCF, Plaghki L, Masquelier E, Hatem SM.



Characterising the short-term habituation of event-related evoked potentials


Mancini F, Pepe A, Di Stefano G, Mouraux A, Iannetti GD.

5(5): ENEURO.0014-18.2018


Quickly-responding C-fiber nociceptors contribute to heat hypersensitivity in the area of secondary hyperalgesia

Journal of Physiology

Lenoir C, Plaghki L, Mouraux A, van den Broeke EN.

in press


Habituation of phase-locked local field potentials and gamma-band oscillations recorded from the human insula

Nature: Scientific Reports

Liberati G, Algoet M, Klöcker A, Ferrao Santos S, Ribeiro-Vaz JG, Raftopoulos C, Mouraux A.

8(1): 8265



Electrophysiological techniques to study the supraspinal responses to nociceptive input in humans

Pain persistence after surgery and altered central processing: science and clinical practice

Mouraux A.

Wilder-Smith OHG, Arendt-Nielsen L, Yarnitski D and Vissers K (Eds). IASP Press


Looking at the hand modulates the brain responses to nociceptive and non-nociceptive somatosensory stimuli but does not necessarily modulate their perception


Torta DM, Legrain V, Mouraux A.


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