Cool-evoked brain potentials (CEPs)

A few studies showed that brisk innocuous cooling of the skin can be used to elicit CEPs related to the activation of cool-sensitive Adelta fibers [34, 41]. However, the responses reported in these previous studies had a low signal-to-noise ratio (SNR), probably due to the limited cooling ramps achieved by the cooling devices, leading to poor time-locking of the activity generatedin cool-sensitive afferents. Recently, we recorded CEPs using a thermode prototype developed by Pr A. Dufour (Strasbourg University) [42]. The device is able to generate very steep cooling ramps of up to 300°C/s. Brisk innocuous cooling of the skin using such ramps elicit CEPs with a high SNR, opening new possibilities to study cool and cold perception in humans.

Researchers involved

Publications

2020

Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

10: 22319

2020

Assessing thermal sensitivity using transient heat and cold stimuli combined with a Bayesian adaptive method in a clinical setting: a proof of concept study

European Journal of Pain

Courtin AS, Maldonado Slootjes S, Caty G, Hermans MP, Plaghki L, Mouraux A.

24(9):1812-1821.

2020

Dynamics of the perception and EEG signals triggered by tonic warm and cool stimulation

PLoS ONE

Mulders D, de Bodt C, Lejeune N, Courtin A, Liberati G, Verleysen M, Mouraux A.

15(4):e0231698

2018

Spatial Filtering of EEG Signals to Identify Periodic Brain Activity Patterns

Latent Variable Analysis and Signal Separation LVA/ICA

Mulders D, de Bodt C, Lejeune N, Mouraux A, Verleysen M.

In: Deville Y, Gannot S, Mason R, Plumbley M, Ward D (eds). Lecture notes in Computer Science, vol 10891. Springer

2018

Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans

Clinical Neurophysiology

De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A.

129(5):1011-1019

2013

Capturing with EEG the neural entrainment and coupling underlying sensorimotor synchronization to the beat

Cerebral Cortex

Nozaradan S, Zerouali Y, Peretz I, Mouraux A.

25(3):736-47

2006

Psychophysical study of the effects of topical application of menthol in healthy volunteers

Pain

Hatem S, Attal N, Willer JC, Bouhassira D.

122(1-2):190-196

2005

Innocuous skin cooling modulates perception and neurophysiological correlates of brief CO2 laser stimuli in humans

European Journal of Pain

Nahra H, Plaghki L.

9(5):521-530

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

NOCIONS : PAIN RESEARCH AT UCLOUVAIN