Cool-evoked brain potentials (CEPs)
A few studies showed that brisk innocuous cooling of the skin can be used to elicit CEPs related to the activation of cool-sensitive Adelta fibers [34, 41]. However, the responses reported in these previous studies had a low signal-to-noise ratio (SNR), probably due to the limited cooling ramps achieved by the cooling devices, leading to poor time-locking of the activity generatedin cool-sensitive afferents. Recently, we recorded CEPs using a thermode prototype developed by Pr A. Dufour (Strasbourg University) . The device is able to generate very steep cooling ramps of up to 300°C/s. Brisk innocuous cooling of the skin using such ramps elicit CEPs with a high SNR, opening new possibilities to study cool and cold perception in humans.
Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin
Courtin AS, Mouraux A
Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
Nature: Scientific Reports
Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
Assessing thermal sensitivity using transient heat and cold stimuli combined with a Bayesian adaptive method in a clinical setting: a proof of concept study
European Journal of Pain
Courtin AS, Maldonado Slootjes S, Caty G, Hermans MP, Plaghki L, Mouraux A.
Spatial Filtering of EEG Signals to Identify Periodic Brain Activity Patterns
Latent Variable Analysis and Signal Separation LVA/ICA
Mulders D, de Bodt C, Lejeune N, Mouraux A, Verleysen M.
In: Deville Y, Gannot S, Mason R, Plumbley M, Ward D (eds). Lecture notes in Computer Science, vol 10891. Springer
Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans
De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A.
Psychophysical study of the effects of topical application of menthol in healthy volunteers
Hatem S, Attal N, Willer JC, Bouhassira D.