NOCIONS all publications
NOCIONS all publications
Cool-evoked brain potentials (CEPs)
A few studies showed that brisk innocuous cooling of the skin can be used to elicit CEPs related to the activation of cool-sensitive Adelta fibers [34, 41]. However, the responses reported in these previous studies had a low signal-to-noise ratio (SNR), probably due to the limited cooling ramps achieved by the cooling devices, leading to poor time-locking of the activity generatedin cool-sensitive afferents. Recently, we recorded CEPs using a thermode prototype developed by Pr A. Dufour (Strasbourg University) [42]. The device is able to generate very steep cooling ramps of up to 300°C/s. Brisk innocuous cooling of the skin using such ramps elicit CEPs with a high SNR, opening new possibilities to study cool and cold perception in humans.
Researchers involved
Publications
2023
Spatial summation of cold and warm detection: evidence for increased precision when brisk stimuli are delivered over larger area
Neuroscience Letters
Courtin AS, Delvaux A, Dufour A, Mouraux A
in press.
2022
Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin
J Pain
Courtin AS, Mouraux A
23(5):754-771.
2020
Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
Nature: Scientific Reports
Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.
10: 22319
2020
Assessing thermal sensitivity using transient heat and cold stimuli combined with a Bayesian adaptive method in a clinical setting: a proof of concept study
European Journal of Pain
Courtin AS, Maldonado Slootjes S, Caty G, Hermans MP, Plaghki L, Mouraux A.
24(9):1812-1821.
2020
Dynamics of the perception and EEG signals triggered by tonic warm and cool stimulation
PLoS ONE
Mulders D, de Bodt C, Lejeune N, Dufour A, Verleysen M, Mouraux A.
15(4):e0231698
2018
Spatial Filtering of EEG Signals to Identify Periodic Brain Activity Patterns
Latent Variable Analysis and Signal Separation LVA/ICA
Mulders D, de Bodt C, Lejeune N, Mouraux A, Verleysen M.
In: Deville Y, Gannot S, Mason R, Plumbley M, Ward D (eds). Lecture notes in Computer Science, vol 10891. Springer
2018
Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans
Clinical Neurophysiology
De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A.
129(5):1011-1019
2013
Capturing with EEG the neural entrainment and coupling underlying sensorimotor synchronization to the beat
Cerebral Cortex
Nozaradan S, Zerouali Y, Peretz I, Mouraux A.
25(3):736-47
2006
Psychophysical study of the effects of topical application of menthol in healthy volunteers
Pain
Hatem S, Attal N, Willer JC, Bouhassira D.
122(1-2):190-196
2005
Innocuous skin cooling modulates perception and neurophysiological correlates of brief CO2 laser stimuli in humans
European Journal of Pain
Nahra H, Plaghki L.
9(5):521-530