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Cool-evoked brain potentials (CEPs)

A few studies showed that brisk innocuous cooling of the skin can be used to elicit CEPs related to the activation of cool-sensitive Adelta fibers [34, 41]. However, the responses reported in these previous studies had a low signal-to-noise ratio (SNR), probably due to the limited cooling ramps achieved by the cooling devices, leading to poor time-locking of the activity generatedin cool-sensitive afferents. Recently, we recorded CEPs using a thermode prototype developed by Pr A. Dufour (Strasbourg University) [42]. The device is able to generate very steep cooling ramps of up to 300°C/s. Brisk innocuous cooling of the skin using such ramps elicit CEPs with a high SNR, opening new possibilities to study cool and cold perception in humans.

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Researchers involved



Spatial summation of cold and warm detection: evidence for increased precision when brisk stimuli are delivered over larger area

Neuroscience Letters

Courtin AS, Delvaux A, Dufour A, Mouraux A

in press.


Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin

J Pain

Courtin AS, Mouraux A



Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

10: 22319


Assessing thermal sensitivity using transient heat and cold stimuli combined with a Bayesian adaptive method in a clinical setting: a proof of concept study

European Journal of Pain

Courtin AS, Maldonado Slootjes S, Caty G, Hermans MP, Plaghki L, Mouraux A.



Dynamics of the perception and EEG signals triggered by tonic warm and cool stimulation


Mulders D, de Bodt C, Lejeune N, Dufour A, Verleysen M, Mouraux A.



Spatial Filtering of EEG Signals to Identify Periodic Brain Activity Patterns

Latent Variable Analysis and Signal Separation LVA/ICA

Mulders D, de Bodt C, Lejeune N, Mouraux A, Verleysen M.

In: Deville Y, Gannot S, Mason R, Plumbley M, Ward D (eds). Lecture notes in Computer Science, vol 10891. Springer


Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans

Clinical Neurophysiology

De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A.



Capturing with EEG the neural entrainment and coupling underlying sensorimotor synchronization to the beat

Cerebral Cortex

Nozaradan S, Zerouali Y, Peretz I, Mouraux A.




Psychophysical study of the effects of topical application of menthol in healthy volunteers


Hatem S, Attal N, Willer JC, Bouhassira D.



Innocuous skin cooling modulates perception and neurophysiological correlates of brief CO2 laser stimuli in humans

European Journal of Pain

Nahra H, Plaghki L.


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