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Cool-evoked brain potentials (CEPs)

A few studies showed that brisk innocuous cooling of the skin can be used to elicit CEPs related to the activation of cool-sensitive Adelta fibers [34, 41]. However, the responses reported in these previous studies had a low signal-to-noise ratio (SNR), probably due to the limited cooling ramps achieved by the cooling devices, leading to poor time-locking of the activity generatedin cool-sensitive afferents. Recently, we recorded CEPs using a thermode prototype developed by Pr A. Dufour (Strasbourg University) [42]. The device is able to generate very steep cooling ramps of up to 300°C/s. Brisk innocuous cooling of the skin using such ramps elicit CEPs with a high SNR, opening new possibilities to study cool and cold perception in humans.

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Researchers involved

Publications

2023

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Spatial summation of cold and warm detection: evidence for increased precision when brisk stimuli are delivered over larger area

Neuroscience Letters

Courtin AS, Delvaux A, Dufour A, Mouraux A

in press.

2022

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Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin

J Pain

Courtin AS, Mouraux A

23(5):754-771.

2020

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Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

10: 22319

2020

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Assessing thermal sensitivity using transient heat and cold stimuli combined with a Bayesian adaptive method in a clinical setting: a proof of concept study

European Journal of Pain

Courtin AS, Maldonado Slootjes S, Caty G, Hermans MP, Plaghki L, Mouraux A.

24(9):1812-1821.

2020

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Dynamics of the perception and EEG signals triggered by tonic warm and cool stimulation

PLoS ONE

Mulders D, de Bodt C, Lejeune N, Dufour A, Verleysen M, Mouraux A.

15(4):e0231698

2018

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Spatial Filtering of EEG Signals to Identify Periodic Brain Activity Patterns

Latent Variable Analysis and Signal Separation LVA/ICA

Mulders D, de Bodt C, Lejeune N, Mouraux A, Verleysen M.

In: Deville Y, Gannot S, Mason R, Plumbley M, Ward D (eds). Lecture notes in Computer Science, vol 10891. Springer

2018

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Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans

Clinical Neurophysiology

De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A.

129(5):1011-1019

2013

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Capturing with EEG the neural entrainment and coupling underlying sensorimotor synchronization to the beat

Cerebral Cortex

Nozaradan S, Zerouali Y, Peretz I, Mouraux A.

25(3):736-47

2006

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Psychophysical study of the effects of topical application of menthol in healthy volunteers

Pain

Hatem S, Attal N, Willer JC, Bouhassira D.

122(1-2):190-196

2005

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Innocuous skin cooling modulates perception and neurophysiological correlates of brief CO2 laser stimuli in humans

European Journal of Pain

Nahra H, Plaghki L.

9(5):521-530

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