The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.
The role of ongoing oscillation in pain perception: Absence of modulation by a concomitant arithmetic task
Leu C, Courtin A, Cussac C, Liberati G.
Pinprick-induced gamma-band oscillations are not a useful electrophysiological marker of pinprick hypersensitivity in humans
Gousset S, Torta DM, Mouraux A, Lambert J, van den Broeke EN.
Influence of skin type and laser wavelength on laser evoked potentials
Eur J Pain
Frahm KS, Gervasio S, Arguissain F, Mouraux A
Comparison between pupillometry and numeric pain rating scale for pain assessments in communicating adult patients in the emergency department
Eur J Pain
Gregoire C, Charier D, de Bergeyck R, Mouraux A, Van Ouytsel F, Lambert R, Zhou N, Lavand'homme P, Penaloza A, Pickering G.
Why Europe needs a pain research strategy
Eur J Pain
Pickering G, O'Keeffe M, Bannister K, Becker S, Cottom S, Cox FJ, Eisenberg E, Finn DP, Graven-Nielsen T, Meeus M, Mouraux A, Tölle T, Garcia-Larrea L, Fullen BM.
Poor pre-operative performance at Clock Drawing Test is associated with postoperative decline in olfaction in older patients: an observational pilot study
Van Regemorter V, Coulie R, Dollase J, Momeni M, Stouffs A, Quenon L, Mouraux A, Huart C
Characterizing biased visuospatial perception in complex regional pain syndrome
Eur J Pain
Filbrich L, Kuzminova A, Molitor V, Verfaille C, Mouraux D, Berquin A, Barbier O, Libouton X, Legrain V
Pain-free default mode network connectivity contributes to tonic experimental pain intensity beyond the role of negative mood and other pain-related factors
Eur J Pain
Alhajri N, Boudreau SA, Mouraux A, Graven-Nielsen T.
Intra-operative electroencephalogram frontal alpha-band spectral analysis and postoperative delirium in cardiac surgery: A prospective cohort study
Eur J Anaesthesiol
Khalifa C, Lenoir C, Robert A, Watremez C, Kahn D, Mastrobuoni S, Aphram G, Ivanoiu A, Bonhomme V, Mouraux A, Momeni M.
Atypical influence of biomechanical knowledge in Complex Regional Pain Syndrome-towards a different perspective on body representation
Filbrich L, Verfaille C, Vannuscorps G, Berquin A, Barbier O, Libouton X, Fraselle V, Mouraux D, Legrain V
Perceptual simultaneity between nociceptive and visual stimuli depends on their spatial congruence
Exp Brain Res
Manfron L, Filbrich L, Molitor V, Farnè A, Mouraux A, Legrain V
The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking
Clinical Neurophysiology Practice
Pia H, Nochi Z, Kristensen AG, Pelz B, Goetz M, Hoeink JN, Blockeel AJ, Mouraux A, Truini A, Finnerup NB, Phillips KG, Treede RD, Tankisi H
Basic, translational and clinical pain research at the Institute of Neuroscience (IoNS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute.
Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.
The main research interest of the team led by Valery Legrain is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).
The group of Giulia Liberati aims to characterize how transient and sustained pain are represented in the human brain, taking advantage of the high temporal and spatial resolution of intracerebral electroencephalography (iEEG). She is particularly interested in investigating the role of the human insula in nociception and pain perception, as several findings suggest that this brain region plays a crucial role in the integration of sensory, affective, and cognitive dimensions of pain.
The research group of Prof. Emmanuel Hermans has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.
At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.