Pain research at UCLouvain

Institute of Neuroscience (IONS)

The ability to perceive pain is crucial for survival, but pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals, and imposes a severe financial burden upon our societies. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.

Recent publications

New insights into cutaneous laser stimulation – dependency on skin and laser type


Frahm KS, Gervasio S, Arguissain F, Mouraux A.

Investigating perceptual simultaneity between nociceptive and visual stimuli by means of temporal order judgments

Neuroscience Letters

Manfron L, Filbrich L, Nijs E, Mouraux A, Legrain V.

Does motor cortex engagement during movement preparation differentially inhibit nociceptive processing in patients with chronic whiplash associated disorders, chronic fatigue syndrome and healthy controls? An experimental study

Journal of Clinical Medicine

Goudman L, Mouraux A, Daenen L, Nijs J, Cras P, Roussel N, Moens M, Lenoir D, Coppieters I, Huysmans E, De Kooning M.

Dynamics of the perception and EEG signals triggered by tonic warm and cool stimulation


Mulders D, de Bodt C, Lejeune N, Courtin A, Liberati G, Verleysen M, Mouraux A.

Assessing thermal sensitivity using transient heat and cold stimuli combined with a Bayesian adaptive method in a clinical setting: a proof of concept study

European Journal of Pain

Courtin AS, Maldonado Slootjes S, Caty G, Hermans MP, Plaghki L, Mouraux A.

Central sensitization of nociceptive pathways demonstrated by robot-controlled pinprick-evoked brain potentials

Clinical Neurophysiology

van den Broeke EN, de Hemptinne P, Mercken M, Torta DM, Lambert J, Mouraux A.

Capsaicin-induced skin desensitization differentially affects A-delta and C-fiber mediated heat sensitivity

Frontiers in Pharmacology

van Neerven SGA, Mouraux A.

Early gamma-oscillations as correlate of localized nociceptive processing in primary sensorimotor cortex

Journal of Neurophysiology

Heid C, Mouraux A, Treede RD, Schuh-Hofer S, Rupp A, Baumgärtner U.

Rating the Intensity of a Laser Stimulus, but Not Attending to Changes in Its Location or Intensity Modulates the Laser-Evoked Cortical Activity

Frontiers in Human Neuroscience

Torta DME, Ninghetto M, Ricci R, Legrain V.

Within- and between-session reliability of secondary hyperalgesia induced by electrical high-frequency stimulation

European Journal of Pain

Cayrol T, Lebleu J, Mouraux A, Roussel N, Pitance L, van den Broeke E.

Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls: a case-control study

Pain Medicine

Goudman L, Daenen L, Mouraux A, Nijs J, Cras P, Roussel N, Moens M, Coppieters I, Huysmans E, De Kooning M.

Rating the intensity of a laser stimulus, but not attending to changes in its location or intensity modulates the laser-evoked cortical activity

Frontiers in Human Neuroscience

Torta DME, Ninghetto M, Ricci R, Legrain V.

Basic, translational and clinical pain research at the Institute of Neuroscience (IONS). Better understanding the neural processes underlying the perception of pain and developing novel means to diagnose and manage chronic pain conditions constitutes the core objective of several research groups and clinicians within our institute.

Research group led by André Mouraux (IONS/COSY)

Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

Research group led by Valéry Legrain (IONS/COSY)

The main research interest of the team led by Valery Legrain is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Different approaches are used: neurophysiology (event-related brain potentials), cognitive psychology (mental chronometry) and neuropsychology (investigation of patients with sensory-motor or attentional deficits).

Research team led by Emmanuel Hermans (IONS/CEMO)

The research group of Prof. Emmanuel Hermans has a long-standing expertise in the use of animal models to study the neuroinflammation and plastic changes of the central nervous system induced by neurotrauma, and its involvement in the development of neuropathic pain. His laboratory has experience in the production of animal models of neuropathic pain, the techniques used to study the pain behaviour of these animals, and the immune-histological techniques to characterize the glial activation and changes in nociceptive pathways at peripheral, spinal and supra-spinal level.

Clinical pain research at the University Hospital

At the Cliniques universitaires Saint Luc, the Department of Anaesthesiology is involved in several clinical research projects focusing on the problematic of chronic post-operative pain. The multidisciplinary Chronic Pain Consultation led by Prof. Anne Berquin is involved in clinical research projects aiming at improving the multidisciplinary management of patients with chronic pain, including the development of new psychophysical techniques to assess patients with neuropathic pain, new bio-psycho-social approaches for the care of patients with chronic regional pain syndrome and chronic widespread pain.


Institute of Neuroscience (IoNS)

53 Avenue Mounier, B1200, Brussels, Belgium

+32(0)2 764 54 47

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Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)