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Alexandre Stouffs

amouraux.jpg

I participated in the Innovative Medicines Initiative (IMI PAIN-CARE; https://www.imi-paincare.eu) project, subtopic BioPain. The aim of this subtopic is to identify and validate a number of functional biomarkers based on non-invasive measures of neural activity (peripheral measures of nerve excitability, spinal and brainstem reflexes, measures of brain activity using electroencephalography [EEG] and functional magnetic resonance imaging [MRI] that can be used in humans to assess the effects of a given drug on the nociceptive system. If successful, these biomarkers would be used in future studies for the early stages of the pharmacological development of novel treatments for pain, and back-translated to animal models.

Group members

Publications

2023

Poor pre-operative performance at Clock Drawing Test is associated with postoperative decline in olfaction in older patients: an observational pilot study

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BMC Anesthesiology

Van Regemorter V, Coulie R, Dollase J, Momeni M, Stouffs A, Quenon L, Mouraux A, Huart C

23:295

2022

Olfactory dysfunction predicts frailty and poor postoperative outcome in older patients scheduled for elective non-cardiac surgery

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J Nutr Health Aging

Van Regemorter V, Dollase J, Coulie R, Stouffs AD, de Saint-Hubert M, Mouraux A, Huart C.

in press.

2022

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

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Trials

Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.

23(1):163.

2021

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).

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Trials

Mouraux A, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Di Stefano G, Finnerup NB, Garcia-Larrea L, Goetz M, Kostenko A, Pelz B, Pogatzki-Zahn E, Schubart K, Stouffs A, Truini A, Tracey I, Troconiz IF, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Treede RD.

22(1):404.

2021

Human surrogate models of central sensitization: a critical review and practical guide

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European Journal of Pain

Quesada C, Kostenko A, Ho I, Leone C, Nochi Z, Stouffs A, Wittayer M, Caspani O, Finnerup NB, Mouraux A, Pickering G, Tracey I, Truini A, Treede RD, Garcia-Larrea L.

25(7):1389-1428.

2020

Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study

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Royal Society Open Science

van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM

8(1):200830.

2019

Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation

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Journal of Neurophysiology

van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.

122(3):994-1001

2019

IMI-PAINCARE, BIOPAIN : validation chez l'homme de nouveaux biomarqueurs fonctionnels pour le développement pharmacologique de traitements de la douleur

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Douleur et Analgésie

Stouffs A, Lebrun L, Mouraux A.

31(4): 230

2018

Philips Intellivue NMT module: variability of initial measurements

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Journal of Clinical Monitoring and Computing

Stouffs A, Ibsen A, Jamart J, Dubois V, Dubois PE.

32(5): 965-966

2016

Intraoperatively diagnosed tracheal tear during a parathyroidectomy with previously undiagnosed tracheomalacia: a case report

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Acta Anaesthesiologica Belgica

Stouffs A, Scholtes JL.

67(4): 197-199

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