NOCIONS all publications
NOCIONS all publications
Roberta Gualdani - Principal Investigator
My research project involves looking for recurrent TRP ion channel mutations in patients suffering from severe chronic pain, in order to understand whether there is a genetic predisposition to the development of the pain conditions, and to develop personalized therapies to normalize the activity of the mutant channels. To this end, I combine the most advanced state-of-the-art techniques for the biophysical and pharmacological study of ion channels, including electrophysiology, fluorescence spectroscopy, biochemistry, structural modelling. I have also a wide experience in ion channel drug discovery and in the development of genetically modified mouse models for in vivo experiments.
Group members
Publications
2022
Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors.
Pain
Latragna A, Sabaté San José A, Tsimpos P, Vermeiren S, Gualdani R, Chakrabarti S, Callejo G, Desiderio S, Shomroni O, Sitte M, Kricha S, Luypaert M, Vanhollebeke B, Laumet G, Salinas G, Smith ESJ, Ris L, Bellefroid EJ.
163(8):e927-e941.
2021
Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission
Sci Rep
Kreis A, Desloovere J, Suelves N, Pierrot N, Yerna X, Issa F, Schakman O, Gualdani R, de Clippele M, Tajeddine N, Kienlen-Campard P, Raedt R, Octave JN, Gailly P.
11(1):17600.
2021
Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies
Pharmacol Rep
Cavalluzzi MM, Budriesi R, De Salvia MA, Quintieri L, Piarulli M, Milani G, Gualdani R, Micucci M, Corazza I, Rosato A, Viale M, Caputo L, Franchini C, Lentini G.
73(1):172-184.
2020
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design
Drug Discov Today
Cavalluzzi MM, Imbrici P, Gualdani R, Stefanachi A, Mangiatordi GF, Lentini G, Nicolotti O.
25(2):344-366.
2020
Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release
eNeuro
Opsomer R, Contino S, Perrin F, Gualdani R, Tasiaux B, Doyen P, Vergouts M, Vrancx C, Doshina A, Pierrot N, Octave JN, Gailly P, Stanga S, Kienlen-Campard P.
7(3):ENEURO.0322-19.2020.
2020
Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction
Int J Mol Sci
Tajeddine N, Tissir F, Gualdani R, Gailly P.
21(5):1712.
2020
Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells
Sci Signal
Gualdani R, Seghers F, Yerna X, Schakman O, Tajeddine N, Achouri Y, Tissir F, Devuyst O, Gailly P.
3(653):eabc6967.
2019
Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma
Cancers (Basel)
Gualdani R, de Clippele M, Ratbi I, Gailly P, Tajeddine N.
11(3):430.
2019
Superparamagnetic iron oxide nanoparticles (SPIONs) modulate hERG ion channel activity
Nanotoxicology
Gualdani R, Guerrini A, Fantechi E, Tadini-Buoninsegni F, Moncelli MR, Sangregorio C.
13(9):1197-1209.
2018
Drug Interactions With the Ca2+-ATPase From Sarco(Endo)Plasmic Reticulum (SERCA)
Front Mol Biosci
Tadini-Buoninsegni F, Smeazzetto S, Gualdani R, Moncelli MR.
5:36.
2018
Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory
Front Cell Neurosci
Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F, Gailly P.
12:318.
2018
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole
Cell Physiol Biochem
Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A, Lentini G.
45(6):2233-2245.