The aim of my project is to assess how intracerebral Periodic Stimulation (iPS) in insular regions entrains pain-related brain oscillations and modulates pain perception. I will uncover this relationship through intracerebral EEG (iEEG) signals recorded from patients undergoing a presurgical evaluation of intractable epilepsy recruited at Saint-Luc University Clinic (UCLouvain). The value of this project lies in the opportunity to investigate and stimulate deep brain regions, such as the insula, whose involvement in nociception and pain perception is poorly understood due to their location. I hope that my research will pave the way for novel non-invasive neurostimulation therapies for chronic pain through the direct investigation of how such interventions affect pain-related brain oscillations and pain perception.