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André Mouraux - Principal investigator (IONS/COSY)

Group : 

amouraux.jpg

Using non-invasive functional neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), combined with novel techniques to selectively activate specific classes of nociceptive afferents, the research performed by the team of André Mouraux (IONS/COSY) follows two main axes. First, to understand how the human brain processes nociceptive sensory input and how this leads to the perception of pain. Second, to understand the plastic changes in nociceptive pathways that occur after inflammation, injury or sustained nociceptive input that induce peripheral and central sensitization and may underlie the development of chronic pain in humans.

Publications

2021

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).

Trials

Mouraux A, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Di Stefano G, Finnerup NB, Garcia-Larrea L, Goetz M, Kostenko A, Pelz B, Pogatzki-Zahn E, Schubart K, Stouffs A, Truini A, Tracey I, Troconiz IF, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Treede RD.

22(1):404.

2021

Transcutaneous auricular VNS applied to experimental pain: A paired behavioral and EEG study using thermonociceptive CO2 laser.

PLoS One

Dumoulin M, Liberati G, Mouraux A, Santos SF, El Tahry R.

16(7):e0254480.

2021

Zero gravity induced by parabolic flight enhances automatic capture and weakens voluntary maintenance of visuospatial attention.

NPJ Microgravity

Salatino A, Iacono C, Gammeri R, Chiadò ST, Lambert J, Sulcova D, Mouraux A, George MS, Roberts DR, Berti A, Ricci R.

7(1):29.

2021

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Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder.

J Gambl Stud

Ninghetto M, Belli F, Nobili M, Mouraux A, Ricci R.

in press.

2021

Human surrogate models of central sensitization: a critical review and practical guide

European Journal of Pain

Quesada C, Kostenko A, Ho I, Leone C, Nochi Z, Stouffs A, Wittayer M, Caspani O, Finnerup NB, Mouraux A, Pickering G, Tracey I, Truini A, Treede RD, Garcia-Larrea L.

25(7):1389-1428.

2021

Challenges and opportunities in translational pain research - an opinion paper of the working group on translational pain research of the European Pain Federation (EFIC)

European Journal of Pain

Mouraux A, Bannister K, Becker S, Finn DP, Pickering G, Pogatzki-Zahn E, Graven-Nielsen T.

in press.

2020

Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study

Royal Society Open Science

van den Broeke EN, Vanmaele T, Mouraux A, Stouffs A, Biurrun-Manresa J, Torta DM

8(1):200830.

2020

Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Nature: Scientific Reports

Liberati G, Mulders D, Algoet M, van den Broeke EN, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A.

10: 22319

2020

New insights into cutaneous laser stimulation – dependency on skin and laser type

Neuroscience

Frahm KS, Gervasio S, Arguissain F, Mouraux A.

448:71-84.

2020

Assessing thermal sensitivity using transient heat and cold stimuli combined with a Bayesian adaptive method in a clinical setting: a proof of concept study

European Journal of Pain

Courtin AS, Maldonado Slootjes S, Caty G, Hermans MP, Plaghki L, Mouraux A.

24(9):1812-1821.

2020

Investigating perceptual simultaneity between nociceptive and visual stimuli by means of temporal order judgments

Neuroscience Letters

Manfron L, Filbrich L, Nijs E, Mouraux A, Legrain V.

735:135156.

2020

Central sensitization of nociceptive pathways demonstrated by robot-controlled pinprick-evoked brain potentials

Clinical Neurophysiology

van den Broeke EN, de Hemptinne P, Mercken M, Torta DM, Lambert J, Mouraux A.

131(10):2491-2498.

2020

Within- and between-session reliability of secondary hyperalgesia induced by electrical high-frequency stimulation

European Journal of Pain

Cayrol T, Lebleu J, Mouraux A, Roussel N, Pitance L, van den Broeke E.

24(8):1585-1597.

2020

Does motor cortex engagement during movement preparation differentially inhibit nociceptive processing in patients with chronic whiplash associated disorders, chronic fatigue syndrome and healthy controls? An experimental study

Journal of Clinical Medicine

Goudman L, Mouraux A, Daenen L, Nijs J, Cras P, Roussel N, Moens M, Lenoir D, Coppieters I, Huysmans E, De Kooning M.

9(5): E1520

2020

Capsaicin-induced skin desensitization differentially affects A-delta and C-fiber mediated heat sensitivity

Frontiers in Pharmacology

van Neerven SGA, Mouraux A.

0.885416667

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

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