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Roberta Gualdani - Principal Investigator

Group : 

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My research project involves looking for recurrent TRP ion channel mutations in patients suffering from severe chronic pain, in order to understand whether there is a genetic predisposition to the development of the pain conditions, and to develop personalized therapies to normalize the activity of the mutant channels. To this end, I combine the most advanced state-of-the-art techniques for the biophysical and pharmacological study of ion channels, including electrophysiology, fluorescence spectroscopy, biochemistry, structural modelling. I have also a wide experience in ion channel drug discovery and in the development of genetically modified mouse models for in vivo experiments.

Publications

2023

hERG stereoselective modulation by mexiletine-derived ureas: Molecular docking study, synthesis, and biological evaluation.

Arch Pharm (Weinheim)

Milani G, Budriesi R, Tavazzani E, Cavalluzzi MM, Mattioli LB, Miniero DV, Delre P, Belviso BD, Denegri M, Cuocci C, Rotondo NP, De Palma A, Gualdani R, Caliandro R, Mangiatordi GF, Kumawat A, Camilloni C, Priori S, Lentini G

356(10):e2300116.

2023

Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory

Front Mol Neurosci

Kreis A, Issa F, Yerna X, Jabbour C, Schakman O, de Clippele M, Tajeddine N, Pierrot N, Octave JN, Gualdani R, Gailly P

16:1081657.

2022

A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons

PNAS

Gualdani R, Gailly P, Yuan JH, Yerna X, Di Stefano G, Truini A, Cruccu G, Dib-Hajj SD, Waxman SG.

119(38):e2119630119.

2022

Lipoyl-Based Antagonists of Transient Receptor Potential Cation A (TRPA1) Downregulate Osteosarcoma Cell Migration and Expression of Pro-Inflammatory Cytokines

ACS Pharmacol Transl Sci

Francesconi O, Corzana F, Kontogianni GI, Pesciullesi G, Gualdani R, Supuran CT, Angeli A, Kavasi RM, Chatzinikolaidou M, Nativi C

5(11):1119-1127.

2022

Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors.

Pain

Latragna A, Sabaté San José A, Tsimpos P, Vermeiren S, Gualdani R, Chakrabarti S, Callejo G, Desiderio S, Shomroni O, Sitte M, Kricha S, Luypaert M, Vanhollebeke B, Laumet G, Salinas G, Smith ESJ, Ris L, Bellefroid EJ.

163(8):e927-e941.

2021

PDF

Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission

Sci Rep

Kreis A, Desloovere J, Suelves N, Pierrot N, Yerna X, Issa F, Schakman O, Gualdani R, de Clippele M, Tajeddine N, Kienlen-Campard P, Raedt R, Octave JN, Gailly P.

11(1):17600.

2021

PDF

Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies

Pharmacol Rep

Cavalluzzi MM, Budriesi R, De Salvia MA, Quintieri L, Piarulli M, Milani G, Gualdani R, Micucci M, Corazza I, Rosato A, Viale M, Caputo L, Franchini C, Lentini G.

73(1):172-184.

2021

Trigeminal Neuralgia TRPM8 Mutation: Enhanced Activation, Basal [Ca2+]i and Menthol Response

Neurol Genet

Gualdani R, Yuan JH, Effraim PR, Di Stefano G, Truini A, Cruccu G, Dib-Hajj SD, Gailly P, Waxman SG.

7(1):e550.

2020

PDF

Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design

Drug Discov Today

Cavalluzzi MM, Imbrici P, Gualdani R, Stefanachi A, Mangiatordi GF, Lentini G, Nicolotti O.

25(2):344-366.

2020

PDF

Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release

eNeuro

Opsomer R, Contino S, Perrin F, Gualdani R, Tasiaux B, Doyen P, Vergouts M, Vrancx C, Doshina A, Pierrot N, Octave JN, Gailly P, Stanga S, Kienlen-Campard P.

7(3):ENEURO.0322-19.2020.

2020

How TRPC Channels Modulate Hippocampal Function

Int J Mol Sci

Gualdani R, Gailly P.

21(11):3915.

2020

PDF

Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction

Int J Mol Sci

Tajeddine N, Tissir F, Gualdani R, Gailly P.

21(5):1712.

2020

PDF

Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells

Sci Signal

Gualdani R, Seghers F, Yerna X, Schakman O, Tajeddine N, Achouri Y, Tissir F, Devuyst O, Gailly P.

3(653):eabc6967.

2019

PDF

Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma

Cancers (Basel)

Gualdani R, de Clippele M, Ratbi I, Gailly P, Tajeddine N.

11(3):430.

2019

PDF

Superparamagnetic iron oxide nanoparticles (SPIONs) modulate hERG ion channel activity

Nanotoxicology

Gualdani R, Guerrini A, Fantechi E, Tadini-Buoninsegni F, Moncelli MR, Sangregorio C.

13(9):1197-1209.

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