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Emanuel van den Broeke

The main objective of my research was to study pain - or nociception- induced central nervous system plasticity. Currently, my studies are focused on characterizing changes in nociceptive pathways that lead or contribute to hyperalgesia, and I am, thereby, particularly interested in the phenomenon of "central sensitization"; the increase responsiveness of nociceptive neurons in the central nervous system that generates widespread hyperalgesia ("secondary hyperalgesia").

Group members

Publications

2020

The focus of spatial attention during the induction of central sensitization can modulate the subsequent development of secondary hyperalgesia

Cortex

Filbrich L, van den Broeke E, Legrain V, Mouraux .

124:193-203

2019

Heterosynaptic facilitation of mechanical nociceptive input is dependent on the frequency of conditioning stimulation

Journal of Neurophysiology

van den Broeke EN, Gousset S, Bouvy J, Stouffs A, Lebrun L, van Neerven SGA, Mouraux A.

122(3):994-1001

2019

Central sensitization in humans: Popular phrase or useful concept?

Journal of Psychosomatic Research

van den Broeke EN, Van den Bergh O.

119:51-52

2019

Central sensitization increases the pupil dilation elicited by mechanical pinprick stimulation

Journal of Neurophysiology

van den Broeke EN, Hartgerink DM, Butler J, Lambert J, Mouraux A.

121(5):1621-1632

2018

No evidence of widespread mechanical pressure hyperalgesia after experimentally-induced central sensitization via skin nociceptors

Pain Reports

Cayrol T, Pitance L, Roussel N, Mouraux A, van den Broeke EN.

3(6): e691

2018

Central sensitization and pain hypersensitivity: some critical considerations

F1000 Research

van den Broeke EN.

2018

High frequency electrical stimulation induces a long-lasting enhancement of event-related potentials but does not change the perception elicited by intra-epidermal electrical stimuli delivered to the area of increased mechanical pinprick sensitivity

PLoS One

Manresa JB, Andersen OK, Mouraux A, van den Broeke EN.

13(9):e0203365

2018

Quickly-responding C-fiber nociceptors contribute to heat hypersensitivity in the area of secondary hyperalgesia

Journal of Physiology

Lenoir C, Plaghki L, Mouraux A, van den Broeke EN.

in press

2018

Central sensitization: explanation or phenomenon?

Clinical Psychological Science

van den Broeke EN, Torta DM, Van den Bergh O.

in press

2018

No perceptual prioritization of non-nociceptive vibrotactile and visual stimuli presented on a sensitized body part

Nature: Scientific Reports

Torta D, Filbrich L, van den Broeke E, Legrain V.

8(1):5359

2018

Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans

Clinical Neurophysiology

De Keyser R, van den Broeke E, Courtin A, Dufour A, Mouraux A.

129(5):1011-1019

2017

Phase-locked and non-phase-locked EEG responses to pinprick stimulation before and after experimentally-induced secondary hyperalgesia

Clinical Neurophysiology

van den Broeke EN, de Vries B, Lambert J, Torta DM, Mouraux A.

128(8):1445-1456

2017

Intense pain influences the cortical processing of visual stimuli projected onto the sensitized skin

Pain

Torta DM, van den Broeke EN, Filbrich L, Jacob B, Lambert J, Mouraux A.

158(4):691-697

2016

Central sensitization of mechanical nociceptive pathways is associated with a long-lasting increase of pinprick-evoked brain potentials

Frontiers in Human Neuroscience

van den Broeke E, Lambert J, Huang G, Mouraux A.

0.785416667

2016

Secondary hyperalgesia is mediated by heat-insensitive A-fiber nociceptors

Journal of Physiology

van den Broeke E, Lenoir C, Mouraux A.

594(22):6767-6776

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