Emanuel van den Broeke

The main objective of my research was to study pain - or nociception- induced central nervous system plasticity. Currently, my studies are focused on characterizing changes in nociceptive pathways that lead or contribute to hyperalgesia, and I am, thereby, particularly interested in the phenomenon of "central sensitization"; the increase responsiveness of nociceptive neurons in the central nervous system that generates widespread hyperalgesia ("secondary hyperalgesia").
Group members
Publications
2013
Altered cortical responsiveness to pain stimuli after high frequency electrical stimulation of the skin in patients with persistent pain after inguinal hernia repair
PLoS ONE
van den Broeke EN, Koeslag L, Arendsen LJ, Nienhuijs SW, Rosman C, van Rijn CM, Wilder-Smith OHG, van Goor H.
2013
Negative expectations facilitate mechanical hyperalgesia after high-frequency electrical stimulation of human skin
European Journal of Pain
van den Broeke EN, Geene N, van Rijn CM, Wilder-Smith OH, Oosterman J.
2013
Patients with Persistent Pain after Breast Cancer Treatment Show Enhanced Alpha Activity in Spontaneous EEG
Pain Medicine
van den Broeke EN, Wilder-Smith OH, van Goor H, Vissers KC, van Rijn CM.
2012
The effect of high-frequency conditioning stimulation of human skin on reported pain intensity and event-related potentials
Journal of Neurophysiology
van den Broeke EN, van Heck CH, Ceelen LA, van Rijn CM, van Goor H, Wilder-Smith OH.
108(8): 2276-81
2012
Patients with persistent pain after breast cancer surgery show both delayed and enhanced cortical stimulus processing
The Journal of Pain Res
van den Broeke EN, de Vries M, van Goor H, Vissers KC, van Rijn CM, Wilder-Smith OH.
5: 139-50
2011
Neural correlates of heterotopic facilitation induced after high frequency electrical stimulation of nociceptive pathways
Molecular Pain
van den Broeke EN, van Heck CH, van Rijn CM, Wilder-Smith OH.
07:28
2010
Neurophysiological correlates of nociceptive heterosynaptic long-term potentiation in humans
Journal of Neurophysiology
van den Broeke EN, van Rijn CM, Biurrun Manresa JA, Andersen OK, Arendt-Nielsen L, Wilder-Smith OH.
103(4): 2107-13
2022
Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: A systematic review of observational studies with meta-analysis.
J Oral Rehabil
Cayrol T, Meeus M, Aron V, Gatto C, Mouraux A, Roussel NA, Sallaz L, van den Broeke EN, Pitance L.
49(6):654-670.