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Valéry Legrain - Principal investigator (IONS/COSY)

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The main research interest of the team led by Valery Legrain (IONS/COSY) is to understand the cognitive mechanisms modulating the link between nociception and the conscious perception of pain, and the neurobiological substrates of these cognitive mechanisms. Three lines of research are developed. First, the group's researchers seek to understand and describe the cognitive factors that help modulate nociceptive responses and pain perception (e.g. selective attention, executive functions, multisensory interaction, and hypnosis). They also study whether cognitive functions could prevent the development of central sensitization to pain. Second, the group studies how pain and the central sensitization it can induce disrupt cognitive functioning (i.e. attention, memory, body and spatial representation). The third line of research aims to understand how pain interacts with other sensory modalities, such as vision and proprioception, in order to mentally represent the peripersonal space and to facilitate reaction against potentially damaging stimuli. These topics are studied in healthy volunteers on experimentally-induced pain as well as in patients suffering from chronic pain (e.g. complex regional pain syndrome, fibromyalgia). Different approaches are used: neurophysiology (EEG, ESG, EMG, ERPs, TMS), psychophysics (threshold measurement, mental chronometry) and neuropsychology (study of patients with sensory-motor or attentional deficits).

Group members

Publications

2015

Prisms for pain. Can visuo-motor rehabilitation strategies alleviate chronic pain?

European Journal of Pain

Torta DM, Legrain V, Rossetti Y, Mouraux A.

20(1):64-9

2015

Looking at the hand modulates the brain responses to nociceptive and non-nociceptive somatosensory stimuli but does not necessarily modulate their perception

Psychophysiology

Torta DM, Legrain V, Mouraux A.

52(8):1010-8

2014

EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli

Journal of Cognitive Neuroscience

Colon E, Legrain V, Mouraux A.

26(10):2262-74

2014

Shifting attention between the space of the body and external space. Electrophysiological correlates of visual-nociceptive crossmodal spatial attention

Psychophysiology

Favril L, Mouraux A, Sambo CS, Legrain V.

51(5):464-77

2014

Mapping nociceptive stimuli in a peripersonal frame of reference: Evidence from a temporal order judgment task

Neuropsychologia

De Paepe A, Crombez G, Spence C, Legrain V.

56:219-28

2014

Short trains of intra-epidermal electrical stimulation to elicit reliable behavioral and electrophysiological responses to the selective activation of nociceptors in humans

Neuroscience Letters

Mouraux A, Marot E, Legrain V.

561: 69-73

2013

Theta burst stimulation applied over primary motor and somatosensory cortices produces analgesia unrelated to the changes in nociceptive event-related potentials

PLoS ONE

Torta D, Legrain V, Algoet M, Olivier E, Duqué J, Mouraux A.

20; 8(8): e73263

2013

Unmasking the obligatory components of nociceptive event-related brain potentials

Journal of Neurophysiology

Mouraux A, De Paepe AL, Marot E, Plaghki L, Iannetti GD, Legrain V.

110(10):2312-24

2013

Psychophysical and electrophysiological evidence for nociceptive dysfunction in CRPS

Pain

Caty G, Hu L, Legrain V, Plaghki L, Mouraux A.

154(11):2521-8

2012

How efficient is the orienting of spatial attention to pain? An experimental investigation

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Pain

Van Damme S, Legrain V.

153(6): 1226-1231

2013

Shielding cognition from nociception with working memory

Cortex

Legrain V, Crombez G, Plaghki L, Mouraux A.

49(7):1922-34

2012

Steady-state evoked potentials to study the processing of tactile and nociceptive somatosensory input in the human brain

Neurophysiologie Clinique - Clinical Neurophysiology

Colon E, Legrain V, Mouraux A.

42(5):315-23

2012

Cognitive aspects of nociception and pain. Bridging neurophysiology with cognitive psychology

Neurophysiologie Clinique - Clinical Neurophysiology

Legrain V, Mancini F, Sambo CF, Torta DM, Ronga I, Valentini E.

42(5): 325-36

2012

Activating selectively and reliably nociceptive afferents with concentric electrode stimulation: yes we can, provided that low stimulus intensities are used

Clinical Neurophysiology

Legrain V, Mouraux A.

124(2): 424

2012

Thermal detection thresholds of A-delta and C-fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin

PLoS ONE

Churyukanov M, Plaghki L, Legrain V, Mouraux A.

7(4): e35817

Institute of Neuroscience (IONS) - Université catholique de Louvain (UCL)

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NOCIONS : PAIN RESEARCH AT UCLOUVAIN

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